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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129574PMC
http://dx.doi.org/10.1177/24730114241255358DOI Listing

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Objectives: Benign and malignant intraosseous schwannomas are rare, and primarily documented in case reports. This study aims to elucidate the differences in clinical features and imaging manifestations between these tumors. This will help clinicians identify malignant lesions at an early stage, reliable guide treatment decisions, and accurately predict outcomes.

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Proximal Femoral Intraosseous Schwannoma.

Semin Musculoskelet Radiol

December 2024

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.

Intraosseous schwannoma is a rare benign nerve sheath tumor comprising < 1% of bone tumors. Relatively common locations for this tumor include the skull and mandible, and, to a lesser degree, the spine and sacrum. Intraosseous schwannoma involving the appendicular skeleton is exceedingly rare.

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Benign peripheral nerve sheath tumors (BPNSTs) are a vast, common, heterogeneous group of lesions that are often diagnostically challenging. The head and neck region is recognized as the second most common location for these lesions, especially the tongue. However, BPNSTs occurring centrally within the jaw bones are exceedingly rare.

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A 40-year-old female presented with right mandibular swelling. A panoramic radiograph showed a unilocular radiolucency from the mandibular angle to tooth #46. Biopsy confirmed a schwannoma.

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Article Synopsis
  • This study analyzes the distribution and types of benign and malignant lesions in the hindfoot and ankle over a 12.5-year period, showing that the majority of cases (81.9%) were soft tissue lesions, with a smaller portion being osseous lesions (18.1%).
  • Of the reviewed cases, 77 were benign and 9 were malignant, leading to an overall malignancy rate of 8.6%, with malignant cases seen primarily in older patients (mean age of 59.2 years).
  • The findings emphasize the importance of accurate imaging and pathology assessment, as benign lesions are more common but malignant tumors can present similarly and should be taken seriously, especially in ambiguous cases
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