AI Article Synopsis
Article Abstract
The vasa vasorum of the large pulmonary vessels is involved in the pathology of COVID-19. This specialized microvasculature plays a major role in the biology and pathology of the pulmonary vessel walls. We have evidence that thrombosis of the vasa vasorum of the large and medium-sized pulmonary vessels during severe COVID-19 causes ischemia and subsequent death of the pulmonary vasculature endothelium. Subsequent release of thrombi from the vasa interna into the pulmonary circulation and pulmonary embolism generated at the ischemic pulmonary vascular endothelium site, are the central pathophysiological mechanisms in COVID-19 responsible for pulmonary thromboembolism. The thrombosis of the vasa vasorum of the large and medium-sized pulmonary vessels is an internal event leading to pulmonary thromboembolism in COVID-19.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129857 | PMC |
| http://dx.doi.org/10.4322/acr.2024.491 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis.
Nat Cardiovasc Res
December 2024
Department of Medicine 2, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Atherosclerosis is a pervasive contributor to ischemic heart disease and stroke. Despite the advance of lipid-lowering therapies and anti-hypertensive agents, the residual risk of an atherosclerotic event remains high, and developing therapeutic strategies has proven challenging. This is due to the complexity of atherosclerosis with a spatial interplay of multiple cell types within the vascular wall.
View Article and Find Full Text PDFRedo Cardiac Surgery After Personalized External Aortic Root Support Operation.
JACC Case Rep
November 2024
Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
A 36-year-old man with Marfan syndrome underwent mitral surgery after personalized external aortic root support operation. Redo surgery was performed without aortic cannulation (with right axillary cannulation and retrograde cardioplegia). Surgical findings revealed unique aortic changes with adventitial growth and vasa vasorum, without visible mesh.
View Article and Find Full Text PDFAge-related changes in the biochemical composition of the human aorta and their correlation with the delamination strength.
Acta Biomater
December 2024
Department of Composites and Carbon Materials, Institute of Rock Structure and Mechanics, Czech Academy of Sciences, 182 09 Prague 8, Czech Republic.
Various studies have correlated the mechanical properties of the aortic wall with its biochemical parameters and inner structure. Very few studies have addressed correlations with the cohesive properties, which are crucial for understanding fracture phenomena such as aortic dissection, i.e.
View Article and Find Full Text PDFMyeloid GSK3α Deficiency Reduces Lesional Inflammation and Neovascularization during Atherosclerotic Progression.
Int J Mol Sci
October 2024
The Thrombosis and Atherosclerosis Research Institute, Hamilton, ON L8L 2X2, Canada.
The molecular mechanisms by which cardiovascular risk factors promote the development of atherosclerosis are poorly understood. We have recently shown that genetic ablation of myeloid glycogen synthase kinase (GSK)-3α attenuates atherosclerotic lesion development in low-density lipoprotein receptor-deficient (Ldlr) mice. However, the precise contributions of GSK3α/β in atherogenesis are not known.
View Article and Find Full Text PDFINFLAMMATORY FACTORS IN DISSECTION OF THORACIC AORTIC ANEURYSM.
Georgian Med News
October 2024
1Petrovsky National Research Center of Surgery, 119435, Moscow; 4Рeoples' Friendship University of Russia named after Patrice Lumumba (RUDN University), 117198, Moscow, Russia.
Unlabelled: In recent years, the prevalence of thoracic aortic aneurysm has increased, and in most cases this pathological condition is diagnosed accidentally. The aim of the current study was to determine the relationship of clinical, laboratory and morphological data with the presence of aorta wall dissection in patients with thoracic aortic aneurysm to reveal factors associated with aorta dissection.
Materials And Methods: The following data of 109 patients mean aged of 53 years with thoracic aortic aneurysm (43 patients with aortic dissection) were analyzed: presence/absence of arterial hypertension, indicators of general blood analysis and blood biochemistry, immunomorphological characteristics of the expression of Von Willebrand factor.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!