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| http://dx.doi.org/10.1186/s12967-024-05189-5 | DOI Listing |
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Correction to: TBC1D5 reverses the capability of HIF‑2 in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy.
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Department of Urology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
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Nutrients
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Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China.
Chronic alcohol consumption retards lipophagy, which contributes to the pathogenesis of liver steatosis. Lipophagy-related Rab7 has been presumed as a crucial regulator in the progression of alcohol liver disease despite elusive mechanisms. More importantly, whether or not hepatoprotective quercetin targets Rab7-associated lipophagy disorder is unknown.
View Article and Find Full Text PDFTBC1D5 controls the GTPase cycle of Rab7b.
J Cell Sci
September 2018
Department of Biosciences, Centre for Immune Regulation, University of Oslo, 0316 Oslo, Norway
Rab GTPases are key regulators of intracellular trafficking, and cycle between a GTP-bound active state and a GDP-bound inactive state. This cycle is regulated by guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Several efforts have been made in connecting the correct GEFs and GAPs to their specific Rab.
View Article and Find Full Text PDFControl of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy.
EMBO J
January 2018
Center for Biological Systems Analysis (ZBSA), Faculty of Biology, Albert Ludwigs Universitaet Freiburg, Freiburg, Germany
Retromer is an endosomal multi-protein complex that organizes the endocytic recycling of a vast range of integral membrane proteins. Here, we establish an additional retromer function in controlling the activity and localization of the late endosomal small GTPase RAB7. Surprisingly, we found that RAB7 not only decorates late endosomes or lysosomes, but is also present on the endoplasmic reticulum, -Golgi network, and mitochondrial membranes, a localization that is maintained by retromer and the retromer-associated RAB7-specific GAP TBC1D5.
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