AI Article Synopsis
- Outdoor air pollution and particulate matter (PM) are known to cause lung cancer and may also be linked to different types of blood cancers, although research on specific subtypes is limited.
- The study utilized data from the American Cancer Society to analyze the impact of various air pollutants on adult haematologic cancers, involving over 100,000 participants monitored from 1992 to 2017.
- Findings indicated significant associations between higher concentrations of PM and certain cancers like mantle cell lymphoma, as well as links between nitrogen dioxide and carbon monoxide with specific lymphomas, suggesting previous research might have underestimated these pollutants' effects on blood cancers.
Article Abstract
Background: Outdoor air pollution and particulate matter (PM) are classified as Group 1 human carcinogens for lung cancer. Pollutant associations with haematologic cancers are suggestive, but these cancers are aetiologically heterogeneous and sub-type examinations are lacking.
Methods: The American Cancer Society Cancer Prevention Study-II Nutrition Cohort was used to examine associations of outdoor air pollutants with adult haematologic cancers. Census block group level annual predictions of particulate matter (PM, PM, PM), nitrogen dioxide (NO), ozone (O), sulfur dioxide (SO), and carbon monoxide (CO) were assigned with residential addresses. Hazard ratios (HR) and 95% confidence intervals (CI) between time-varying pollutants and haematologic subtypes were estimated.
Results: Among 108,002 participants, 2659 incident haematologic cancers were identified from 1992-2017. Higher PM concentrations were associated with mantle cell lymphoma (HR per 4.1 μg/m = 1.43, 95% CI 1.08-1.90). NO was associated with Hodgkin lymphoma (HR per 7.2 ppb = 1.39; 95% CI 1.01-1.92) and marginal zone lymphoma (HR per 7.2 ppb = 1.30; 95% CI 1.01-1.67). CO was associated with marginal zone (HR per 0.21 ppm = 1.30; 95% CI 1.04-1.62) and T-cell (HR per 0.21 ppm = 1.27; 95% CI 1.00-1.61) lymphomas.
Conclusions: The role of air pollutants on haematologic cancers may have been underestimated previously because of sub-type heterogeneity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231250 | PMC |
| http://dx.doi.org/10.1038/s41416-024-02718-3 | DOI Listing |
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