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Post-Normal Science (PNS) was introduced about 30 years ago to address the changing relation between science and governance when science is called upon to provide inputs to policy-related issued. Originally concerned mainly with environmental risks, in the last decades the PNS approach has been applied to a growing and diversified number of issues. It is considered particularly appropriate in situations characterized by: uncertain facts, a plurality of potentially conflicting values, high stakes, and urgent decisions.
View Article and Find Full Text PDFCountermeasures and follow-up actions in response to information on thyroid cancer, which possibly provoked misunderstanding and unfounded rumour, issued by five former Japanese prime ministers.
Radiat Prot Dosimetry
November 2024
Department of Radiation Health Management, Fukushima Medical University School of Medicine, Hikarigaoka-1 Fukushima City, Fukushima, Japan.
This study summarises the responses to information on thyroid cancer, which possibly provoked misunderstanding and unfounded rumour, described in a letter issued by five former Japanese Prime Ministers on 27 January, 2022. Fukushima Medical University (FMU) implemented countermeasures and follow-up in three phases in response to the letter. In Phase 1, FMU shared scientific facts on the relationship between radiation exposure and thyroid cancer, as well as the response of FMU towards those who read the letter and were concerned about the description.
View Article and Find Full Text PDFA novel near-infrared fluorescent probe for butyrylcholinesterase: Research for screening of natural anti-AD inhibitors.
Anal Chim Acta
December 2024
Experimental Center, Shandong University of Traditional Chinese Medicine, Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Jinan, 250355, China. Electronic address:
Elevated levels of butyrylcholinesterase (BuChE) have the potential to be predictive in the timely detection and diagnosis of Alzheimer's disease (AD). By inhibiting of BuChE activity can raise acetylcholine levels and intervene AD processes. Therefore, BuChE as an important factor in treatment AD has been given more and more attention in clinical studies.
View Article and Find Full Text PDFSpecies-specific trends of plutonium, radiocesium, and potassium-40 levels in three fish species of the Yenisei river (Siberia, Russia).
J Environ Radioact
December 2024
All-Russian Research Institute for Silviculture and Mechanization of Forestry, 15 Institutskaya str., Pushkino, 141202, Russia.
Article Synopsis
- * Results indicate no increase in plutonium levels in fish after major discharges from 2018-2020, but grayling had significantly higher Pu concentrations due to their diet of benthic invertebrates, while larger pike showed increasing Pu levels.
- * High concentrations of radiocesium and potassium were found in pike, attributed to biomagnification, leading to potential ecological risk assessments and a foundation for future research on radionuclides in freshwater ecosystems.
Tanshinone IIA potentiates the chemotherapeutic effect of doxorubicin against breast cancer cells and attenuates the cardiotoxicity of doxorubicin by regulating ERK1/2 pathway.
J Biochem Mol Toxicol
October 2024
Department of Clinical Laboratory, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Doxorubicin (Dox) is frequently employed as a chemotherapy agent for breast cancer. As the chemotherapy moves forward, breast cancer cells tend to develop resistance to Dox, besides that, Dox are also easy to cause cardiotoxicity related to cumulative dose. Therefore, how to potentiate the chemosensitivity of breast cancer cells to Dox while attenuating its cardiotoxicity has become a research hotspot.
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