AI Article Synopsis
- Molluscum contagiosum virus (MCV) is a member of the Poxviridae family, specifically belonging to the genus Molluscipoxvirus, and it primarily infects human skin tissue.* -
- After an incubation period of 2 to 6 weeks, MCV leads to skin lesions called papules, influenced by the individual's immune response, and it does not enter the bloodstream.* -
- Infection is common in children and immunocompromised individuals, and while treatments exist, including immunomodulators, they often lack effectiveness in managing MCV-induced lesions.*
Article Abstract
Molluscum contagiosum virus is a poxvirus belonging to the Poxviridae family, which includes Orthopoxvirus, Parapoxvirus, Yantapoxvirus, Molluscipoxvirus, Smallpox virus, Cowpox virus and Monkeypox virus. MCV belongs to the genus Molluscipoxvirus and has a tropism for skin tissue. MCV infects keratinocytes and, after an incubation period of 2 weeks to 6 weeks, causes a breakdown of the skin barrier with the development of papules of variable size depending on the proper functioning of the immune response (both adaptive and acquired). MCV only infects humans and does not cause viraemia. MCV encodes for several inhibitory proteins responsible to circumvent the immune response through different signalling pathways. Individuals who can be infected with MCV are children, immunocompromised individuals such as organ transplant recipients and Human Immunodeficiency Virus (HIV)-infected individuals. Current treatments to manage MCV-induced lesions are different and include the use of immunomodulators, which, however, do not provide an effective response.
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| http://dx.doi.org/10.1007/978-3-031-57165-7_10 | DOI Listing |
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