Background: Melanoma is rare as a secondary malignant neoplasm among childhood cancer survivors.
Case: We report a case of a 12-year-old boy who developed malignant melanoma with systemic metastases 17 months after completing treatment for hepatoblastoma. The diagnosis was made unexpectedly based on a bone marrow examination. The patient did not respond to immune checkpoint inhibitor therapy and died 6 weeks after being diagnosed with melanoma. Whole-exome sequencing to examine 103 genes associated with cancer predisposition did not identify any germ-line variants.
Conclusion: This case study provides a unique example of melanoma in a childhood cancer survivor following hepatoblastoma treatment but does not identify any candidate variant to link hepatoblastoma and melanoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129619 | PMC |
| http://dx.doi.org/10.1002/cnr2.2118 | DOI Listing |
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