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| http://dx.doi.org/10.1016/j.jdin.2024.03.020 | DOI Listing |
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Metabolic Profiling of Individuals with Missing Teeth and Tooth Loss.
J Dent Res
January 2025
Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Missing teeth have been linked to incident cardiovascular disease, diabetes, and all-cause mortality. Our previous study revealed that signs of oral infections and inflammatory conditions (i.e.
View Article and Find Full Text PDFDeveloping and assessing the "MultiLife" intervention: a mobile health-based lifestyle toolkit for cardiometabolic multimorbidity in diabetes and hypertension management - a type 1 hybrid effectiveness-implementation trial protocol.
BMC Public Health
January 2025
Indian Council of Medical Research, New Delhi, India.
Background: Cardiometabolic multimorbidity (CMM), characterized by the coexistence of diabetes, hypertension, and cardiovascular disease, poses a major health challenge in India, particularly in rural areas with limited healthcare resources. Lifestyle interventions can manage cardiometabolic risk factors, yet adherence remains suboptimal. Mobile health (mHealth) interventions offer a scalable approach for managing CMM by promoting behaviour change and medication adherence.
View Article and Find Full Text PDFAdipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits.
Nat Genet
January 2025
Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Complete characterization of the genetic effects on gene expression is needed to elucidate tissue biology and the etiology of complex traits. In the present study, we analyzed 2,344 subcutaneous adipose tissue samples and identified 34,774 conditionally distinct expression quantitative trait locus (eQTL) signals at 18,476 genes. Over half of eQTL genes exhibited at least two eQTL signals.
View Article and Find Full Text PDFGlobal consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR).
J Nutr Health Aging
December 2024
Faculty of Medicine and Health, School of Health Sciences and Sydney Medical School, University of Sydney, New South Wales, Australia, and Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, United States.
Article Synopsis
- Aging leads to physiological changes and increased disease vulnerability, culminating in higher mortality rates as individuals get older.
- Regular physical activity (PA) and exercise can counteract aging effects, improve health span, and reduce the risk of chronic diseases such as heart disease and cancer.
- Personalized exercise plans, including various forms of training like aerobic and resistance exercises, are essential for maintaining health and functionality in older adults, particularly those with age-related issues.
Subphenotypes of body composition and their association with cardiometabolic risk - Magnetic resonance imaging in a population-based sample.
Metabolism
December 2024
Department of Diagnostic and Interventional Radiology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Epidemiology, Helmholtz Munich, Neuherberg, Germany. Electronic address:
Background: For characterizing health states, fat distribution is more informative than overall body size. We used population-based whole-body magnetic resonance imaging (MRI) to identify distinct body composition subphenotypes and characterize associations with cardiovascular disease (CVD) risk.
Methods: Bone marrow, visceral, subcutaneous, cardiac, renal, hepatic, skeletal muscle and pancreatic adipose tissue were measured by MRI in n = 299 individuals from the population-based KORA cohort.
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