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Group ICA of wide-field calcium imaging data reveals the retrosplenial cortex as a major contributor to cortical activity during anesthesia. | LitMetric

AI Article Synopsis

  • Large-scale cortical dynamics are essential for cognitive functions like motor learning and sensory processing, with different brain states (like wakefulness and anesthesia) influencing neuronal activity.
  • This study used Independent Component Analysis on wide-field imaging of mouse cortical activity to explore how various brain states affect cortical networks, identifying patterns common across subjects.
  • Findings showed that certain cortical regions, especially the retrosplenial cortices, were more active during deeper anesthesia, while awake states exhibited a more diverse range of cortical dynamics.

Article Abstract

Large-scale cortical dynamics play a crucial role in many cognitive functions such as goal-directed behaviors, motor learning and sensory processing. It is well established that brain states including wakefulness, sleep, and anesthesia modulate neuronal firing and synchronization both within and across different brain regions. However, how the brain state affects cortical activity at the mesoscale level is less understood. This work aimed to identify the cortical regions engaged in different brain states. To this end, we employed group ICA (Independent Component Analysis) to wide-field imaging recordings of cortical activity in mice during different anesthesia levels and the awake state. Thanks to this approach we identified independent components (ICs) representing elements of the cortical networks that are common across subjects under decreasing levels of anesthesia toward the awake state. We found that ICs related to the retrosplenial cortices exhibited a pronounced dependence on brain state, being most prevalent in deeper anesthesia levels and diminishing during the transition to the awake state. Analyzing the occurrence of the ICs we found that activity in deeper anesthesia states was characterized by a strong correlation between the retrosplenial components and this correlation decreases when transitioning toward wakefulness. Overall these results indicate that during deeper anesthesia states coactivation of the posterior-medial cortices is predominant over other connectivity patterns, whereas a richer repertoire of dynamics is expressed in lighter anesthesia levels and the awake state.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116703PMC
http://dx.doi.org/10.3389/fncel.2024.1258793DOI Listing

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