Marchaetoglobins A-D: Four Cytochalasans with Proangiogenic Activity from the Marine-Sponge-Associated Fungus 162105.

Four new cytochalasans, marchaetoglobins A-D (), along with five known compounds (), were isolated from the marine-sponge-associated fungus 162105. Compounds represent examples of 19,20--chaetoglobosins, of which compound is the first furan-containing cytochalasan. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses and electronic circular dichroism calculations. Compounds , , and displayed weak to moderate antibacterial activities against , , , and pv. with minimum inhibitory concentration values ranging from 5 to 25 μg/mL. In addition, compounds , , and showed potent proangiogenic activity in transgenic zebrafish, comparable to the positive control.