AI Article Synopsis
- The study compared the effects of time-restricted eating (TRE) and daily calorie restriction (CR) on weight loss and sex hormone levels in adults with obesity over 12 months.
- Both TRE and CR led to significant weight loss in males and females, while the control group did not lose weight.
- Despite weight loss, levels of testosterone, DHEA, SHBG in males, and estradiol, estrone, and progesterone in postmenopausal females remained unchanged across all groups, indicating that TRE does not affect sex hormone levels.
Article Abstract
Unlabelled: This study examined the effects of time restricted eating (TRE) on sex hormones in males and females, versus daily calorie restriction (CR). Adults with obesity (n = 90) were randomized to 1 of 3 groups for 12-months: 8-h TRE (eating only between 12:00 to 8:00 pm, with no calorie counting); CR (25% energy restriction daily); or control. Body weight decreased (P < 0.01) in the TRE and CR groups, relative to controls, in males, premenopausal females, and postmenopausal females, by month 12. Total testosterone, dehydroepiandrosterone (DHEA), and sex hormone binding globulin (SHBG) levels did not change over time, or between groups, in males, premenopausal females, and postmenopausal females. Estradiol, estrone, and progesterone were only measured in postmenopausal females, and remained unchanged. These findings suggest that TRE produces significant weight loss but does not impact circulating sex hormone levels in males and females with obesity over 12 months, relative to CR and controls.
Trial Registration: Clinicaltrials.gov , NCT04692532 .
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11118632 | PMC |
| http://dx.doi.org/10.1101/2024.05.15.24307415 | DOI Listing |
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