This paper addresses the critical gaps in existing AI risk management frameworks, emphasizing the neglect of human factors and the absence of metrics for socially related or human threats. Drawing from insights provided by NIST AI RFM and ENISA, the research underscores the need for understanding the limitations of human-AI interaction and the development of ethical and social measurements. The paper explores various dimensions of trustworthiness, covering legislation, AI cyber threat intelligence, and characteristics of AI adversaries. It delves into technical threats and vulnerabilities, including data access, poisoning, and backdoors, highlighting the importance of collaboration between cybersecurity engineers, AI experts, and social-psychology-behavior-ethics professionals. Furthermore, the socio-psychological threats associated with AI integration into society are examined, addressing issues such as bias, misinformation, and privacy erosion. The manuscript proposes a comprehensive approach to AI trustworthiness, combining technical and social mitigation measures, standards, and ongoing research initiatives. Additionally, it introduces innovative defense strategies, such as cyber-social exercises, digital clones, and conversational agents, to enhance understanding of adversary profiles and fortify AI security. The paper concludes with a call for interdisciplinary collaboration, awareness campaigns, and continuous research efforts to create a robust and resilient AI ecosystem aligned with ethical standards and societal expectations.
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http://dx.doi.org/10.3389/fdata.2024.1381163 | DOI Listing |
Transl Behav Med
January 2025
Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center, Tampa, FL, 33162, USA.
Background: Results of the National Lung Screening Trial create the potential to reduce lung cancer mortality, but community translation of lung cancer screening (LCS) has been challenging. Subsequent policies have endorsed informed and shared decision-making and using decision support tools to support person-centered choices about screening to facilitate implementation. This study evaluated the feasibility and acceptability of LuCaS CHOICES, a web-based decision aid to support delivery of accurate information, facilitate communication skill development, and clarify personal preferences regarding LCS-a key component of high-quality LCS implementation.
View Article and Find Full Text PDFCurr Med Chem
January 2025
Shree S K Patel College of Pharmaceutical Education and Research, Ganpat University, Mahesana, Gujarat, 384012, India.
Therapeutic hurdles persist in the fight against lung cancer, although it is a leading cause of cancer-related deaths worldwide. Results are still not up to par, even with the best efforts of conventional medicine, thus new avenues of investigation are required. Examining how immunotherapy, precision medicine, and AI are being used to manage lung cancer, this review shows how these tools can change the game for patients and increase their chances of survival.
View Article and Find Full Text PDFJACC Adv
December 2024
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Rheumatic heart disease (RHD) is an important public health problem in Africa. Mapping the epidemiology of RHD involves elucidating its geographic distribution, temporal trends, and demographic characteristics. The prevalence of RHD in Africa varies widely, with estimates ranging from 2.
View Article and Find Full Text PDFJACC Adv
December 2024
Division of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
This state-of-the-art review examines disparities in the diagnosis, management, and outcomes of cardiac arrhythmias globally. These arrhythmias include atrial fibrillation, ventricular tachyarrhythmias underlying sudden cardiac death, and bradyarrhythmias associated with sinus node and atrioventricular node disease. Arrhythmias in low- and middle-income countries often result in higher mortality rates due to complex and poorly documented risk factors, lack of clinical expertise among health care personnel, lack of sufficient infrastructure, and challenges in access to care.
View Article and Find Full Text PDFACS Pharmacol Transl Sci
January 2025
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, 22525 Hamburg, Germany.
The SARS-CoV-2 papain-like protease PLpro has multiple roles in the viral replication cycle, related to both its polypeptide cleavage function and its ability to antagonize the host immune response. Targeting the PLpro function is recognized as a promising mechanism to modulate viral replication, while supporting host immune responses. However, the development of PLpro-specific inhibitors remains challenging.
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