Levetiracetam is widely used in the emergency setting. Safety and tolerability of undiluted levetiracetam is prevalent in adults but is limited in pediatrics. The purpose is to determine the safety and tolerability of rapid administration of undiluted levetiracetam in pediatric patients. A retrospective, single-center, observational study was conducted in pediatric patients who received undiluted levetiracetam intravenous push. The primary outcome was adverse reactions, extravasation, need for intravenous line replacement, and discontinuation due to adverse reactions. The secondary outcome was turnaround time between ordering and administering first doses. One hundred fourteen patients were included. Injection site reactions occurred in 7 patients. Extravasation occurred in 4 patients. Two patients required intravenous line replacement. There were no adverse events leading to discontinuation of levetiracetam. No difference was seen in the time from order to administration. Rapid administration of undiluted levetiracetam in pediatric patients was safe and well tolerated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/08830738241255992 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Safety and tolerability of intravenous undiluted levetiracetam in pediatrics: A retrospective cohort study.
Epilepsia
December 2024
Department of Pharmacy, John Muir Health - Walnut Creek Medical Center, Walnut Creek, California, USA.
Article Synopsis
- Time sensitivity is crucial for treating acute seizures, and reducing delays in medication preparation can enhance treatment effectiveness.
- This study analyzed the safety and tolerability of IV undiluted levetiracetam in pediatric patients, focusing on adverse drug events related to concentration.
- Results showed no concentration-related adverse events in 60 administrations among 52 patients, suggesting that IV undiluted levetiracetam is safe and tolerable for children, though further prospective studies are needed.
Efficiency and safety of high-dose undiluted intravenous push levetiracetam loading doses compared to intravenous infusion in seizing patients: A retrospective cohort study.
Epilepsia
October 2024
Department of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts, USA.
Objective: Intravenous (IV) push (IVP) is an alternative administration method for levetiracetam, but evidence evaluating it compared to IV piggyback (IVPB) for loading doses in acutely seizing patients is limited, particularly in patients with status epilepticus (SE). This study aimed to compare the efficiency and safety of IVP versus IVPB levetiracetam loading doses.
Methods: This was a single-center sequential retrospective study conducted in adult (≥18 years) patients who received an IV levetiracetam loading dose (>2000 mg or ≥20 mg/kg) for acute or suspected seizure.
Comment on "Evaluation of the safety and tolerability of intravenous undiluted levetiracetam at a pediatric institution".
Pharmacotherapy
May 2024
Department of Neurosurgery, Affiliated hospital of Jining medical University, Jining, China.
Response to comment on "Evaluation of the safety and tolerability of intravenous undiluted levetiracetam at a pediatric institution".
Pharmacotherapy
May 2024
Division of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Determining the Safety and Tolerability of Rapid Administration of Undiluted Intravenous Levetiracetam in Pediatrics.
J Child Neurol
June 2024
Department of Pediatrics, UMass Chan Medical School, Worcester, MA, USA.
Levetiracetam is widely used in the emergency setting. Safety and tolerability of undiluted levetiracetam is prevalent in adults but is limited in pediatrics. The purpose is to determine the safety and tolerability of rapid administration of undiluted levetiracetam in pediatric patients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!