AI Article Synopsis
- The study aimed to investigate how anticholinergic medication affects cognitive performance in individuals with Parkinson's disease (PD) without dementia.
- Researchers analyzed data from 493 PD patients, assessing their medications using the anticholinergic cognitive burden scale (ACBS) and comparing their performance across cognitive domains and distinct cognitive phenotypes.
- Results showed no significant relationship between anticholinergic burden and cognitive performance, suggesting that medication use does not influence cognitive differences in this PD population.
Article Abstract
Objective: Cognitive changes are heterogeneous in Parkinson's disease (PD). This study compared whether anticholinergic burden drives differences in cognitive domain performance and empirically-derived PD-cognitive phenotypes.
Method: A retrospective chart review contained participants (n = 493) who had idiopathic PD without dementia. Participants' medications were scored (0-3) and summed based on the anticholinergic cognitive burden scale (ACBS). We examined the ACBS' relationship to five cognitive domain composites (normative z-scores) and three (K-means clustering based) cognitive phenotypes: cognitively intact, low executive function (EF), and predominately impaired EF/memory. Analyses included Spearman correlations, analysis of covariance, and Pearson chi-squared test.
Results: Overall, phenotypes did not differ in anticholinergic burden, and (after false-discovery-rate corrections) no cognitive domains related. When comparing those above and below the clinically relevant ACBS cutoff (i.e., score ≥3), no significant phenotype or domain differences were found.
Conclusions: Anticholinergic medication usage did not drive cognitive performance in a large clinical sample of idiopathic PD without dementia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586454 | PMC |
| http://dx.doi.org/10.1093/arclin/acae041 | DOI Listing |
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