AI Article Synopsis
- Fetal imaging studies are used to assess the prognosis of congenital diaphragmatic hernia (CDH) and the need for therapy, but recent findings suggest these predictions may not be accurate anymore due to improved survival rates.
- A study on 58 left-sided CDH cases revealed that contemporary survival rates were significantly higher across all severity classifications compared to past studies, indicating that current prognostic criteria are outdated.
- The authors argue that these overly pessimistic imaging criteria could result in unnecessary fetal interventions, stressing the need for new prognostic guidelines in future research.
Article Abstract
Background: Fetal Centers use imaging studies to predict congenital diaphragmatic hernia (CDH) prognosis and the need for fetal therapy. Given improving CDH survival, we hypothesized that current fetal imaging severity predictions no longer reflect true outcomes and fail to justify the risks of fetal therapy.
Methods: We analyzed our single-center contemporary data in a left-sided CDH cohort (n = 58) by prognostic criteria determined by MRI observed-to-expected total fetal lung volumes: severe <25%, moderate 25-35%, and mild >35%. We compared contemporary survival to prior studies and the TOTAL trials.
Results: Contemporary survival was significantly higher than past studies for all prognostic classifications (mild 100% vs 80-94%, moderate 95% vs 59-75%, severe 79% vs 13-25%; P < 0.01), and to either control or fetal therapy arms of the TOTAL trials.
Conclusions: Current fetal imaging criteria are overly pessimistic and may lead to unwarranted fetal intervention. Fetal therapies remain experimental. Future studies will require updated prognostic criteria.
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| http://dx.doi.org/10.1038/s41372-024-02008-z | DOI Listing |
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