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Lectin Receptors in Primary and Metastatic Cancer Cells.
Asian Pac J Cancer Prev
November 2024
Department of Pathological Anatomy, Forensic Medicine, Histology, Donetsk National Medical University, Kropyvnytskyi, Ukraine.
Purpose: The purpose of this study was to detect the distribution of different lectin receptors in primary cancer cells as well as in the case of metastasis, as these biomolecules can potentially predict cancer development in certain tissues and systems.
Methods: To detect lectin receptors in tumors, the authors used conjugates of lectins purified by affinity chromatography with peroxidase, and studied their localization in paraffin sections of 12 cases of primary cancer and 33 of its metastases.
Result: In primary cancers and their metastases, there is a distinct mosaicity in the histotopography of individual lectins, especially peanut and soybean lectin.
Antibacterial and anticancer activities of three novel lectin-conjugated chitosan nanoparticles.
Appl Microbiol Biotechnol
November 2024
Department of Botany, Faculty of Science, Ain Shams University, Cairo, Egypt.
To the best of our knowledge, this is the first attempt to synthesize, characterize, and determine the antibacterial and anticancer effects of three novel conjugates of plant lectins: phytohemagglutinin lectin (PHA), soybean agglutinin (SBA), and peanut agglutinin (PNA) with chitosan nanoparticles (CHNPs). The lectin concentration within prepared conjugates was estimated using nannodrop, and the highest concentration was 0.96 mg/ml in PHA-CHNPs.
View Article and Find Full Text PDFLectin histochemistry in the small intestines of piglets naturally infected with porcine epidemic diarrhea virus.
J Vet Sci
September 2024
College of Veterinary Medicine and Host-Directed Antiviral Research Center, Chonnam National University, Gwangju 61186, Korea.
Importance: Porcine epidemic diarrhea virus (PEDV) binds to particular cell surface receptors to penetrate cells. The virus specifically identifies certain carbohydrate structures present on the surface of the cell to facilitate the binding process. Nevertheless, the influence of viral infections on specific alterations of glycoconjugates in the small intestines remains unexplored.
View Article and Find Full Text PDFCyclodextrin-Cholesterol Alone or in Combination With Cyclodextrin-Vitamin E Improves Bull Sperm Cryopreservation in a Soybean Lecithin Extender.
Reprod Domest Anim
October 2024
Department of Veterinary Sciences, Laboratoire Environnement, Santé et Production Animale (LESPA), Institute of Veterinary Sciences and Agronomic Sciences, University of Batna 1, Batna, Algeria.
Combining cholesterol-loaded methyl-β-cyclodextrin (CD-CHL) with vitamin E-loaded methyl-β-cyclodextrin (CD-Vit E) to combat cold shock and oxidative stress during sperm cryopreservation in soybean lecithin extenders remains unexplored. Thus, the current study aimed to investigate the effect of treating bull sperm with CD-CHL and CD-Vit E prior to cryopreservation in a soybean lecithin extender. Sperm collected from eight fertile bulls were pooled and split into six aliquots.
View Article and Find Full Text PDFAnalysis of neuraminidase activity of human parainfluenza viruses using enzyme-linked lectin assay and BTP3-Neu5Ac assay.
Microbiol Immunol
November 2024
Virus Research Center, Clinical Research Division, Sendai Medical Center, National Hospital Organization, Sendai, Japan.
Human parainfluenza viruses (hPIVs) are causative agents of upper and lower respiratory tract infections and they have four serotypes. The virion surface displays hemagglutinin-neuraminidase (HN), having hemagglutinating (HA) and neuraminidase (NA) activities in a single molecule. The HA activity binds the virion to sialic acid on the viral receptor on host cells and the NA releases the progeny viruses from the cell surface.
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