Regulatory effects of Astragalus membranaceus polysaccharides on lipid metabolism disorders induced by a high-fat diet in spotted sea bass (Lateolabrax maculatus).

Int J Biol Macromol

Fisheries College, Jimei University, Xiamen, China; Fujian Provincial Key Laboratory of Marine Fishery Resources and Eco-environment, Xiamen, China. Electronic address:

Published: June 2024

AI Article Synopsis

  • - This study explored how Astragalus membranaceus polysaccharides (AMP) can counteract lipid metabolism issues in spotted sea bass caused by a high-fat diet (HFD) that was 15% lipids compared to a normal diet of 10% lipids.
  • - After 56 days of feeding with varying levels of AMP, results showed that AMP reduced liver damage and malonaldehyde levels in fish, although it did not significantly impact serum lipids or abdominal fat amounts.
  • - Overall, the findings suggest that incorporating AMP into aquaculture may help manage lipid metabolism disorders caused by high-fat diets in fish, particularly improving liver health.

Article Abstract

This study evaluated the regulatory effects of Astragalus membranaceus polysaccharides (AMP) on lipid metabolism disorders induced by a high-fat diet (HFD) in spotted sea bass (Lateolabrax maculatus). Compared with the normal diets (10 % lipids), diets containing 15 % lipid levels were used as the high-fat diet (HFD). Three levels of the AMP (0.06 %, 0.08 %, 0.10 %) were added in the HFD and used as experimental diets. A total of 375 spotted sea bass (average weight 3.00 ± 0.01 g) were divided into 15 tanks and deemed as 5 groups, with each tank containing 25 fish. Fish in each group were fed with different diets for 56 days. After feeding, the HFD induced lipid metabolism disorders in fish, as evidenced by elevated serum lipids, malonaldehyde levels, and more severe liver damage. The AMP alleviated the HFD-induced liver damage, as evidenced by the reduced severity of liver histological lesions and malonaldehyde levels. The low-density lipoprotein cholesterol was reduced, and the expression of FAS and PPAR-α were down and up-regulated, respectively. However, the AMP had a limited ability to affect the serum lipids and abdominal fat percentage. These results reveal the potential of the AMP used in aquaculture to regulate lipid metabolism disorders induced by the HFD.

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Source
http://dx.doi.org/10.1016/j.ijbiomac.2024.132584DOI Listing

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