AI Article Synopsis
- Recent studies show that circular RNAs (circRNAs) play an important role in the growth of colorectal cancer (CRC).
- A protein called EIF4A3 helps create these circRNAs and helps CRC cells grow by interacting with circEIF4A3.
- The study found that circEIF4A3 works like a helper for EIF4A3 and helps cells survive by promoting a process called autophagy, which is important for cell health.
Article Abstract
Recent studies indicate that circular RNAs (circRNAs) are crucial in the progression of colorectal cancer (CRC). Eukaryotic translation initiation factor 4A3 (EIF4A3) has been identified as a promoter of circRNA production. The biological roles and mechanisms of EIF4A3-derived circRNA (circEIF4A3) in CRC cell autophagy remain poorly understood. This study explores the effects of circEIF4A3 on CRC cell growth and autophagy, aiming to elucidate the underlying molecular mechanisms. We discovered that EIF4A3 and circEIF4A3 synergistically enhance CRC cell growth. CircEIF4A3 sequesters miR-3126-5p, consequently upregulating EIF4A3. Further, circEIF4A3 increases EIF4A3 expression, which promotes autophagy by stabilizing ATG5 mRNA and enhances ATG7 protein stability through the stabilization of USP14 mRNA, a deubiquitinating enzyme. Upregulation of ATG5 and ATG7 counteracts the growth-inhibitory effects of EIF4A3 knockdown on CRC cells. Moreover, our findings demonstrate that EIF4A3 induces the formation of circEIF4A3 in CRC cells. In conclusion, a positive feedback loop between circEIF4A3 and EIF4A3 supports CRC cell growth by facilitating autophagy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153236 | PMC |
| http://dx.doi.org/10.1016/j.tranon.2024.101996 | DOI Listing |
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