Chitosan, a versatile biopolymer derived from chitin, has garnered significant attention in various biomedical applications due to its unique properties, such as biocompatibility, biodegradability, and mucoadhesiveness. This review provides an overview of the diverse applications of chitosan and its derivatives in the antibacterial, anticancer, wound healing, and tissue engineering fields. In antibacterial applications, chitosan exhibits potent antimicrobial properties by disrupting microbial membranes and DNA, making it a promising natural preservative and agent against bacterial infections. Its role in cancer therapy involves the development of chitosan-based nanocarriers for targeted drug delivery, enhancing therapeutic efficacy while minimising side effects. Chitosan also plays a crucial role in wound healing by promoting cell proliferation, angiogenesis, and regulating inflammatory responses. Additionally, chitosan serves as a multifunctional scaffold in tissue engineering, facilitating the regeneration of diverse tissues such as cartilage, bone, and neural tissue by promoting cell adhesion and proliferation. The extensive range of applications for chitosan in pharmaceutical and biomedical sciences is not only highlighted by the comprehensive scope of this review, but it also establishes it as a fundamental component for forthcoming research in biomedicine.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11125164 | PMC |
http://dx.doi.org/10.3390/polym16101351 | DOI Listing |
Technol Cancer Res Treat
December 2024
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
Objectives: This study developed a drug delivery system (DDS) using folic acid (FA)-functionalized chitosan (CS) and poly (lactic-co-glycolic acid) (PLGA) nanocarriers for targeted sodium butyrate (NB) delivery to leukemia cells (NALM6). The goal was to enhance NB's therapeutic efficacy while reducing its cytotoxicity to non-malignant cells.
Methods: FA-CS-PLGA nanocarriers were synthesized and characterized using Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), zeta potential analysis, transmission electron microscopy (TEM), and thermogravimetric analysis (TGA).
Int J Biol Macromol
December 2024
School of Chemistry and Chemical Engineering, Yantai University, Shandong Province, 264005, China. Electronic address:
Although the natural antibacterial agent, cinnamaldehyde, has been extensively studied in the field of food packaging, its water solubility and instability limit its further applications. The controllable responsive release can be achieved through encapsulation in responsive emulsion systems based on carboxymethyl chitosan. Herein, a pH-responsive antibacterial emulsion gel was constructed from cinnamaldehyde-loaded oil-in-water emulsion templates.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
AI Agri-Tech Research Center, Chonnam National University, Gwangju 61186, Republic of Korea; Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju 61186, Republic of Korea; BK21 Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address:
Hydrogels in agriculture offer controlled release, however, face issues with rapid disintegration, swift release, and inability to protect active ingredients. To overcome this, the study presents a hydrogel delivery system that uses dopamine-functionalized nanoporous diatom (DE-PDA) microparticles entrapped in alginate and chitosan matrices to deliver plant growth hormone, gibberellic acid (GA) that suffers from instability, limiting its field application. Developed GA@hydrogel beads exhibited an encapsulation efficiency of 85.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Biochemistry and Biomaterials Research Laboratory, Department of Chemistry, Faculty of Arts and Sciences, İnönü University, 44280 Malatya, Türkiye.
Chitosan/oxidized cellulose blended film with Tribulus terrestris (T. terrestris) extract films were successfully produced by casting method. The obtained blend films were characterized by structural, mechanical, optical, permeation, antioxidant, and antimicrobial properties.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
School of Chemistry and Chemical Engineering, North University of China, No.3 Xueyuan Road, Jiancaoping District, Taiyuan 030051, China.
This study developed PQSp wound dressing hydrogels (S0-S6) using polyvinyl alcohol (PVA), quaternary chitosan (QCS), and sodium alginate (SA) as the matrix, with the addition of coconut mesocarp polyphenol (P-CTP, 0.1 %, 0.5 %, and 1.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!