Monitoring hydrogen sulfide (HS) in living organisms is very important because HS acts as a regulator in many physiological and pathological processes. Upregulation of endogenous HS concentration has been shown to be closely related to the occurrence and development of tumors, atherosclerosis, neurodegenerative diseases and diabetes. Herin, a novel fluorescent probe with aggregation-induced emission was designed. Impressively, exhibited a high selectivity, fast response (1 min) and low detection limit (0.61 μM) for HS in PBS buffer (10 mM, pH = 7.42). Moreover, the reaction mechanism between and HS was conducted by Job's plot, HR-MS, and DFT. In particular, was successfully employed to detect HS in HeLa cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11124099 | PMC |
| http://dx.doi.org/10.3390/molecules29102386 | DOI Listing |
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