A pharmacokinetic study of ranitidine was performed in 14 patients with haematemesis divided into two groups according to the severity of blood loss. Pharmacokinetic values were calculated from plasma concentrations after the first of three daily injections (100 mg) and compared with those obtained in five healthy volunteers (50 mg i.v.). There were no significant differences between patients in the two haemorrhage groups and controls. The low, or even questionable, effectiveness of histamine H2-receptor antagonists in the treatment of upper gastrointestinal haemorrhage does not seem to be due to pharmacokinetic factors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1400845 | PMC |
| http://dx.doi.org/10.1111/j.1365-2125.1985.tb05133.x | DOI Listing |
Publication Analysis
Top Keywords
upper gastrointestinal
8
gastrointestinal haemorrhage
8
haemorrhage pharmacokinetic
8
pharmacokinetics ranitidine
4
ranitidine acute
4
acute upper
4
pharmacokinetic study
4
study ranitidine
4
ranitidine performed
4
performed patients
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!