AI Article Synopsis
- The study examined the link between coronary microvascular dysfunction (CMD) and inflammation using inflammatory markers from complete blood count (CBC) analysis.
- Researchers analyzed data from a cohort of angina patients with non-obstructive coronary arteries, focusing on ratios like neutrophil-to-lymphocyte (NLR), eosinophil-to-monocyte (EMR), and monocyte-to-HDL (MHR).
- Results indicated no significant differences in these inflammatory markers between CMD-positive and CMD-negative patients, suggesting that CMD may not be strongly related to inflammation, contrary to previous assumptions.
Article Abstract
Background: Coronary microvascular dysfunction (CMD) is associated with various inflammatory conditions that worsen endothelial dysfunction. This study aimed to investigate the relationship between CMD and inflammation using common inflammatory markers derived from complete blood count (CBC) analysis.
Methods: Information was gathered from the Coronary Microvascular Disease Registry to examine the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-monocyte ratio (EMR), and monocyte-to-high-density lipoprotein ratio (MHR) in a cohort of patients with angina who showed non-obstructive coronary arteries and underwent invasive physiological assessments for CMD.
Results: Of the 171 patients studied, 126 were CMD-negative and 45 were CMD-positive, constituting two groups of interest. The average age of all patients was 61.7 ± 11.1 years, and 63.7 % were female. No significant differences were observed between the two groups in terms of baseline characteristics, cardiovascular risk factors, or potential anti-inflammatory medications. Furthermore, there were no statistically significant differences in NLR (2.54 ± 3.71 vs. 2.52 ± 2.28, p = 0.97), EMR (0.3 ± 0.21 vs. 0.34 ± 0.29, p = 0.31), or MHR (0.02 ± 0.01 vs. 0.01 ± 0.01, p = 0.54) between CMD-positive and CMD-negative patients.
Conclusion: Our findings did not show a noteworthy connection between CMD and inflammation, as suggested by various simple CBC-based biomarkers.
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| http://dx.doi.org/10.1016/j.carrev.2024.05.020 | DOI Listing |
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