The extent to which physical activity and psychological factors may affect the risk of diabetes mellitus among lean individuals remains unclear. This study aimed to investigate the associations of total physical activity (TPA) and psychological factors with lean type 2 diabetes mellitus (T2DM) risk. A prospective cohort study. The study population included 1,945 Korean adults who maintained a body mass index <23 kg/m. Baseline data on TPA and psychological factors were collected and T2DM incidence was assessed for 10 years. For analysis, a multivariable Cox proportional hazards regression model was used. TPA was inversely associated with T2DM risk and this association was more pronounced in participants who were depressed or distressed; the top TPA quartile exhibited significant reductions in T2DM risk of 66% (95% confidence interval [CI]: 0.15, 0.78) and 65% (95% CI: 0.14, 0.88) among participants who reported depressed mood and those who perceived high distress, respectively, compared with the bottom TPA quartile. The current study demonstrated the preventive effects of physical activity on T2DM in lean adults through its interaction with psychological factors.
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| http://dx.doi.org/10.1177/14791641241239618 | DOI Listing |
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