AI Article Synopsis
- Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older adults, with no current prevention methods available.
- Autophagy, the process of cellular recycling, plays a crucial role in the disease, as its dysfunction leads to debris buildup and cell problems in both AMD patients and models.
- Drugs that boost autophagy show potential in slowing AMD progression in preclinical studies, but further human research is necessary, and future treatments may need to be personalized.
Article Abstract
Age-related macular degeneration (AMD) is a major cause of irreversible vision loss in the elderly. Although new therapies have recently emerged, there are currently no ways of preventing the development of the disease. Changes in intracellular recycling processes. Changes in intracellular recycling processes, called autophagy, lead to debris accumulation and cellular dysfunction in AMD models and AMD patients. Drugs that enhance autophagy hold promise as therapies for slowing AMD progression in preclinical models; however, more studies in humans are required. While a definitive cure for AMD will likely hinge on a personalized medicine approach, treatments that enhance autophagy hold promise for slowing vision loss.
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| http://dx.doi.org/10.1016/j.coph.2024.102463 | DOI Listing |
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