AI Article Synopsis

  • HPV is a double-stranded DNA virus that often causes asymptomatic infections, with about 90% resolving on their own, but high-risk strains can lead to cancerous lesions in areas like the cervix and anus.
  • The virus is known to contribute to various malignancies, particularly via its beta strains in skin cancers such as cutaneous squamous cell carcinoma, though its exact role in other skin cancers remains unclear.
  • Recent studies suggest that HPV may also play a role in triggering other skin cancers, like basal cell carcinoma and melanoma, prompting a closer examination of its contributions to both benign and malignant skin lesions.

Article Abstract

The human papillomavirus (HPV) belongs to the Papillomaviridae family of viruses which includes small, double-stranded DNA viral agents. Approximately 90% of HPV infections occur asymptomatically and resolve spontaneously. However, infection with high-risk viral strains can lead to the development of preneoplastic lesions, with an increased propensity to become cancerous. The location of these malignancies includes the oral cavity, cervix, vagina, anus, and vulva, among others. The role of HPV in carcinogenesis has already been demonstrated for the aforementioned neoplasia. However, regarding skin malignancies, the mechanisms that pinpoint the role played by HPV in their initiation and progression still elude our sight. Until now, the only fully understood mechanism of viral cutaneous oncogenesis is that of human herpes virus 8 infection in Kaposi sarcoma. In the case of HPV infection, however, most data focus on the role that beta strains exhibit in the oncogenesis of cutaneous squamous cell carcinoma (cSCC), along with ultraviolet radiation (UVR) and other environmental or genetic factors. However, recent epidemiological investigations have highlighted that HPV could also trigger the onset of other non-melanocytic, for example, basal cell carcinoma (BCC), and/or melanocytic skin cancers, for example, melanoma. Herein, we provide an overview of the role played by HPV in benign and malignant skin lesions with a particular focus on the main epidemiological, pathophysiological, and molecular aspects delineating the involvement of HPV in skin cancers.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11124606PMC
http://dx.doi.org/10.1097/MD.0000000000038202DOI Listing

Publication Analysis

Top Keywords

skin cancers
12
hpv
8
role played
8
played hpv
8
cell carcinoma
8
skin
5
molecular mechanisms
4
mechanisms human
4
human papilloma
4
papilloma virus
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!