AI Article Synopsis
- PFAS, particularly PFOA and PFOS, are linked to negative health effects, prompting a study examining their serum levels across 13,887 participants from various NHANES cycles from 1999-2000 to 2017-2018.
- Analysis revealed overall declining levels of PFOA and PFOS in adults, with higher concentrations found in men, smokers, and individuals with pre-existing health issues like CKD, CVD, and cancer.
- The study indicated that those with diabetes and CKD experienced faster declines in PFOA, while faster reductions in PFOS were noted in individuals with diabetes, suggesting a connection between environmental chemicals and chronic disease trends.
Article Abstract
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are associated with adverse health effects. This study examined the trend of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) levels in individuals with and without pre-existing comorbidities. We analyzed the characteristics of 13,887 participants across nine U.S. NHANES cycles (1999-2000 to 2017-2018) and calculated the geometric mean (GM) of PFOA and PFOS levels, standardized by sex and age. A joinpoint regression model was used to analyze the temporal trends of serum PFOA and PFOS levels. We observed declining PFOA and PFOS serum levels among adults in NHANES from 1999-2000 to 2017-2018. Serum PFOA and PFOS concentrations were higher in men, smokers, and individuals with pre-existing CKD, hyperlipidemia, CVD, and cancer. We observed faster decline rates in PFOA levels among individuals with diabetes and CKD and faster decline rates in PFOS levels among individuals with diabetes and those without CKD. This study provided evidence of varying levels and changing trends of PFOA and PFOS between groups with and without established chronic disease, highlighting the role of environmental chemicals in the onset and development of chronic diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11125848 | PMC |
| http://dx.doi.org/10.3390/toxics12050314 | DOI Listing |
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