Objective: To determine the added value of digital breast tomosynthesis (DBT) in the assessment of lesions detected by contrast-enhanced mammography (CEM).
Material And Methods: A retrospective study was conducted in a tertiary university medical center. All CEM studies including DBT performed between January 2016 and December 2020 were included. Lesions were categorized and scored by four dedicated breast radiologists according to the recent CEM and DBT supplements to the Breast Imaging Reporting and Data System (BIRADS) lexicon. Changes in the BIRADS score of CEM-detected lesions with the addition of DBT were evaluated according to the pathology results and 1-year follow-up imaging study.
Results: BIRADS scores of CEM-detected lesions were upgraded toward the lesion's pathology with the addition of DBT ( > 0.0001), overall and for each reader. The difference in BIRADS scores before and after the addition of DBT was more significant for readers who were less experienced. The reason for changes in the BIRADS score was better lesion margin visibility. The main BIRADS descriptors applied in the malignant lesions were spiculations, calcifications, architectural distortion, and sharp or obscured margins.
Conclusions: The addition of DBT to CEM provides valuable information on the enhancing lesion, leading to a more accurate BIRADS score.
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http://dx.doi.org/10.3390/tomography10050061 | DOI Listing |
J Cell Physiol
January 2025
Department of Biosciences & Bioengineering, IIT Bombay, Mumbai, India.
In addition to proteins such as collagen (Col) and fibronectin, the extracellular matrix (ECM) is enriched with bulky proteoglycan molecules such as hyaluronic acid (HA). However, how ECM proteins and proteoglycans collectively regulate cellular processes has not been adequately explored. Here, we address this question by studying cytoskeletal and focal adhesion organization and dynamics on cells cultured on polyacrylamide hydrogels functionalized with Col, HA and a combination of Col and HA (Col/HA).
View Article and Find Full Text PDFJ Ayurveda Integr Med
January 2025
Centre for Ayurvedic Biology, Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. Electronic address:
Background: Brain ageing is accompanied by the diminution of neuronal plasticity, which is correlated with the inability to respond to loss of memory, various stress-induced stimuli, and increased risk of neurodegenerative disorders. In the recent past, plant based herbal medicines are of interest over synthetic drugs for therapeutic purposes due to lower side effects. The Indian traditional medicine Ayurveda describes several herbal remedies, such as rasayana (elixirs for rejuvenation), to treat many age-related diseases.
View Article and Find Full Text PDFCells
December 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee 247667, India.
The quest for cleaner and sustainable energy sources is crucial, considering the current scenario of a steep rise in energy consumption and the fuel crisis, exacerbated by diminishing fossil fuel reserves and rising pollutants. In particular, the bioaccumulation of hazardous substances like trivalent chromium has not only disrupted the fragile equilibrium of the ecological system but also poses significant health hazards to humans. Microalgae emerged as a promising solution for achieving sustainability due to their ability to remediate contaminants and produce greener alternatives such as biofuels.
View Article and Find Full Text PDFBehav Sci (Basel)
December 2024
Departamento de Productividad e Innovación, Universidad de la Costa, Barranquilla 080001, Colombia.
Introduction: Third-generation therapies (TGTs) have been shown to be effective in the treatment of substance use behaviors in college-aged adolescents. These therapies are based on acceptance, mindfulness and psychological flexibility, which enable young people to change their Psychoactive Substance Use (PSU)-related behaviours, develop coping skills to manage difficult emotions and thoughts, reduce experiential avoidance and maintain long-term abstinence.
Objective: To explore the implementation and potential benefits of third-generation therapies, Acceptance and Commitment Therapy (ACT), Dialectical Behaviour Therapy (DBT) and Mindfulness, for the treatment of PSU in college youth.
J Med Imaging (Bellingham)
January 2025
University of Houston, Department of Biomedical Engineering, Houston, Texas, United States.
Purpose: Digital phantoms are one of the key components of virtual imaging trials (VITs) that aim to assess and optimize new medical imaging systems and algorithms. However, these phantoms vary in their voxel resolution, appearance, and structural details. We investigate whether and how variations between digital phantoms influence system optimization with digital breast tomosynthesis (DBT) as a chosen modality.
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