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Titanium Dioxide (TiO) Incorporation into Poly(ether sulfone) (PES) Hollow Fiber Membranes (HFMs) Improves Biocompatibility and Separation Performance for Bioartificial Kidney (BAK) and Hemodialysis Applications.
ACS Appl Bio Mater
January 2025
Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
Hemodialysis and bioartificial kidney (BAK), which mimic both physical and biological functions, can significantly impact chronic kidney disease (CKD) patients. Here we report on Hollow fiber membranes (HFMs) with enhanced separation of uremic toxins along with enhanced hemocompatibility and biocompatibility that also promote the growth of kidney cells. The improvement arises from the addition of titanium dioxide (0.
View Article and Find Full Text PDFStructurally Stable Hollow-Fiber-Based Porous Graphene Oxide Membranes with Improved Rejection Performance by Selective Patching of Framework Defects with Metal-Organic Framework Crystals.
ACS Appl Mater Interfaces
January 2025
Barrer Centre, Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom.
Graphene oxide (GO)-based membranes have demonstrated great potential in water treatment. However, microdefects in the framework of GO membranes induced by the imperfect stacking of GO nanosheets undermine their size-sieving ability and structural stability in aqueous systems. This study proposes a targeted growth approach by growing zeolitic imidazolate framework-8 (ZIF-8) nanocrystals precisely to patch microdefects as well as to cross-link the porous graphene oxide (PGO) flakes coated on the outer surface of the hollow fiber (HF) alumina substrate (named the hybrid PGO/ZIF-8 membrane).
View Article and Find Full Text PDFAnion-Doped Perovskite Oxygen-Permeable Membranes Fabricated via an Improved One-Step Thermal Processing Approach.
Materials (Basel)
December 2024
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, 30 Puzhu Road(S), Nanjing 211816, China.
Anion-doped perovskite membranes with a hollow fiber geometry have excellent oxygen separation performance. However, during the fabrication process of hollow fiber membranes, soaking the precursor in deionized water leads to elemental dissolution, especially anion dissolution. To prevent metal and anion element dissolution, an improved one-step thermal processing approach was proposed in which saturated solutions were used as internal and external coagulation baths, effectively controlling the stoichiometric ratio.
View Article and Find Full Text PDFLong-term in vivo performance of silicone membrane lungs coated with novel methacryloyloxyethyl phosphorylcholine polymers: A pilot study.
Artif Organs
December 2024
Department of Bioengineering, The University of Tokyo Graduate School of Engineering, Tokyo, Japan.
Background: This study was designed to evaluate the long-term durability, oxygenation, and pressure loss of newly developed, methacryloyloxyethyl phosphorylcholine (MPC)-polymer-coated, nonporous silicone hollow fiber-membrane lungs in vivo using a pulmonary artery-to-left-atrium paracorporeal configuration.
Methods: An extracorporeal circuit from the pulmonary artery (device inflow) to the left atrium (device outflow) was established using dedicated composite vascular grafts in three healthy female goats for the prototype lung testing.
Results: Duration of testing the prototype lungs was 52, 57, or 100 days.
What is the feasibility of a clinical-scale and anticoagulation-free artificial placenta device?
Expert Rev Med Devices
November 2024
Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA.
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