Denigrins H-L: Sulfated Derivatives of Denigrins D and E from a New Zealand c.f. Marine Sponge.

Five new sulfated arylpyrrole and arylpyrrolone alkaloids, denigrins H-L (-), along with two known compounds, dictyodendrin B and denigrin G, were isolated from an extract of a New Zealand c.f. marine sponge. Denigrins H-L represent the first examples of sulfated denigrins with denigrins H and I (-), as derivatives of denigrin D, containing a pyrrolone core, and denigrins J-L (-), as derivatives of denigrin E (), containing a pyrrole core. Their structures were elucidated by interpretation of 1D and 2D NMR spectroscopic data, ESI, and HR-ESI-MS spectrometric data, as well as comparison with literature data. Compounds , along with six known compounds previously isolated from the same extract, showed minimal cytotoxicity against the HeLa cervical cancer cell line.