Vaccination arguably remains the only long-term strategy to limit the spread of infections and its related antibiotic resistance. To date, however, all staphylococcal vaccines tested in clinical trials have failed. In this review, we propose that the failure of vaccines is intricately linked to prior host exposure to and the pathogen's capacity to evade adaptive immune defenses. We suggest that non-protective immune imprints created by previous exposure to are preferentially recalled by SA vaccines, and IL-10 induced by S. aureus plays a unique role in shaping these non-protective anti-staphylococcal immune responses. We discuss how modifies the host immune landscape, which thereby necessitates alternative approaches to develop successful staphylococcal vaccines.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11117348 | PMC |
| http://dx.doi.org/10.3390/antibiotics13050410 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Challenges and strategies in the soluble expression of CTA1-(S14P5)4-DD and CTA1-(S21P2)4-DD fusion proteins as candidates for COVID-19 intranasal vaccines.
PLoS One
December 2024
Research Organization for Health, National Research and Innovation (BRIN), Cibinong, Indonesia.
Developing intranasal vaccines against pandemics and devastating airborne infectious diseases is imperative. The superiority of intranasal vaccines over injectable systemic vaccines is evident, but developing effective intranasal vaccines presents significant challenges. Fusing a protein antigen with the catalytic domain of cholera toxin (CTA1) and the two-domain D of staphylococcal protein A (DD) has significant potential for intranasal vaccines.
View Article and Find Full Text PDFfrom Sauerkraut Alleviates Acute Lung Injury Induced by Methicillin-Resistant through the Regulation of M2 Macrophage Polarization via Its Metabolite Esculin.
J Agric Food Chem
January 2025
College of Veterinary Medicine, Jilin Agricultural University, Changchun, Jilin 130018, China.
Sauerkraut contains various fermentative microorganisms that produce active metabolites, enhancing immunity and resistance to infections. However, its effects on methicillin-resistant (MRSA)-induced acute lung injury (ALI) remain unclear. Using RAW264.
View Article and Find Full Text PDFPathobiont-induced suppressive immune imprints thwart T cell vaccine responses.
Nat Commun
December 2024
Department of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.
Pathobionts have evolved many strategies to coexist with the host, but how immune evasion mechanisms contribute to the difficulty of developing vaccines against pathobionts is unclear. Meanwhile, Staphylococcus aureus (SA) has resisted human vaccine development to date. Here we show that prior SA exposure induces non-protective CD4 T cell imprints, leading to the blunting of protective IsdB vaccine responses.
View Article and Find Full Text PDFDespite many attempts, there is currently no approved vaccine to prevent Staphylococcus aureus infections. Preclinical vaccination models have failed to predict vaccine efficacy in humans as S. aureus exposure in humans imprints an immune response that is lacking in naive animals.
View Article and Find Full Text PDFPathobiont-driven antibody sialylation through IL-10 undermines vaccination.
J Clin Invest
December 2024
Division of Infectious Diseases, Department of Pediatrics, University of California, La Jolla, California, USA.
The pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa modifies antibody activity is not clear. Herein, we demonstrate that IL-10 is the decisive factor that abrogates antibody protection in mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!