AI Article Synopsis
- Modern medicine has made strides in treating neurological and neurodegenerative diseases, but the increasing number of patients presents ongoing challenges in effective treatment.
- The unique structure of the blood-brain barrier (BBB) significantly limits drug efficacy, complicating the delivery of effective therapies to the brain.
- Recent studies have explored new molecular delivery pathways that could improve drug delivery to the brain, offering hope for enhanced treatment options and potentially benefiting millions of patients.
Article Abstract
Modern medicine has allowed for many advances in neurological and neurodegenerative disease (ND). However, the number of patients suffering from brain diseases is ever increasing and the treatment of brain diseases remains an issue, as drug efficacy is dramatically reduced due to the existence of the unique vascular structure, namely the blood-brain barrier (BBB). Several approaches to enhance drug delivery to the brain have been investigated but many have proven to be unsuccessful due to limited transport or damage induced in the BBB. Alternative approaches to enhance molecular delivery to the brain have been revealed in recent studies through the existence of molecular delivery pathways that regulate the passage of peripheral molecules. In this review, we present recent advancements of the basic research for these delivery pathways as well as examples of promising ventures to overcome the molecular hurdles that will enhance therapeutic interventions in the brain and potentially save the lives of millions of patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11119906 | PMC |
| http://dx.doi.org/10.3390/cells13100789 | DOI Listing |
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