AI Article Synopsis
- Cystic Echinococcosis (CE) is a disease caused by a tapeworm's larval stage, and this study focuses on using two specific monoclonal antibodies (mAbEmG3 and mAbEm2G11) for diagnosis through immunohistochemistry (IHC).
- The research involved 13 patients suspected of having CE at Sardinian hospitals between 2017 and 2022, with IHC successfully identifying the disease in 12 out of the 13 cases.
- The findings indicate that the use of these antibodies in IHC is a highly effective diagnostic method, especially for cases where other techniques fail to provide clarity.
Article Abstract
Cystic Echinococcosis (CE) is a zoonotic disease caused by the larval stage of the tapeworm . This study aims to investigate the use of two monoclonal antibodies (mAbEmG3 and mAbEm2G11) by immunohistochemistry (IHC) to confirm the diagnosis of CE in human patients, in particular in those cases in which other techniques fail to provide a correct or conclusive diagnosis. For this purpose, a survey on 13 patients was performed. These subjects were referred to Sardinian hospitals (Italy) from 2017 to 2022 and were suspected to be affected by CE. Our findings from these 13 patients showed the detection of by IHC in 12 of 13 echinococcal cysts, as one sample was of a non-parasitological origin. The results confirmed that IHC, by means of the mAbEmG3 and mAbEm2G11, is a reliable diagnostic tool that showed a very high performances when tested on strain of from Sardinia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11119186 | PMC |
| http://dx.doi.org/10.3390/diseases12050084 | DOI Listing |
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