The integration of graph embedding technology and collaborative filtering algorithms has shown promise in enhancing the performance of recommendation systems. However, existing integrated recommendation algorithms often suffer from feature bias and lack effectiveness in personalized user recommendation. For instance, users' historical interactions with a certain class of items may inaccurately lead to recommendations of all items within that class, resulting in feature bias. Moreover, accommodating changes in user interests over time poses a significant challenge. This study introduces a novel recommendation model, RCKFM, which addresses these shortcomings by leveraging the CoFM model, TransR graph embedding model, backdoor tuning of causal inference, KL divergence, and the factorization machine model. RCKFM focuses on improving graph embedding technology, adjusting feature bias in embedding models, and achieving personalized recommendations. Specifically, it employs the TransR graph embedding model to handle various relationship types effectively, mitigates feature bias using causal inference techniques, and predicts changes in user interests through KL divergence, thereby enhancing the accuracy of personalized recommendations. Experimental evaluations conducted on publicly available datasets, including "MovieLens-1M" and "Douban dataset" from Kaggle, demonstrate the superior performance of the RCKFM model. The results indicate a significant improvement of between 3.17% and 6.81% in key indicators such as precision, recall, normalized discount cumulative gain, and hit rate in the top-10 recommendation tasks. These findings underscore the efficacy and potential impact of the proposed RCKFM model in advancing recommendation systems.
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http://dx.doi.org/10.3390/e26050371 | DOI Listing |
With the increasing availability of high-quality genome assemblies, pangenome graphs emerged as a new paradigm in the genomics field for identifying, encoding, and presenting genomic variation at both population and species levels. However, it remains challenging to truly dissect and interpret pangenome graphs via biologically informative visualization. To facilitate better exploration and understanding of pangenome graphs towards novel biological insights, here we present a web-based interactive Visualization and interpretation framework for linear-Reference-projected Pangenome Graphs (VRPG).
View Article and Find Full Text PDFGigascience
January 2025
School of Computer Science, Hunan University of Technology, Zhuzhou 412007, Hunan, China.
Background: The accurate deciphering of spatial domains, along with the identification of differentially expressed genes and the inference of cellular trajectory based on spatial transcriptomic (ST) data, holds significant potential for enhancing our understanding of tissue organization and biological functions. However, most of spatial clustering methods can neither decipher complex structures in ST data nor entirely employ features embedded in different layers.
Results: This article introduces STMSGAL, a novel framework for analyzing ST data by incorporating graph attention autoencoder and multiscale deep subspace clustering.
J Cell Mol Med
January 2025
Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Cancer is a complex disease driven by mutations in the genes that play critical roles in cellular processes. The identification of cancer driver genes is crucial for understanding tumorigenesis, developing targeted therapies and identifying rational drug targets. Experimental identification and validation of cancer driver genes are time-consuming and costly.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Department of Electronic Engineering, Tsinghua University, 100084 Beijing, China.
Single-cell multi-omics techniques, which enable the simultaneous measurement of multiple modalities such as RNA gene expression and Assay for Transposase-Accessible Chromatin (ATAC) within individual cells, have become a powerful tool for deciphering the intricate complexity of cellular systems. Most current methods rely on motif databases to establish cross-modality relationships between genes from RNA-seq data and peaks from ATAC-seq data. However, these approaches are constrained by incomplete database coverage, particularly for novel or poorly characterized relationships.
View Article and Find Full Text PDFNeural Netw
January 2025
Department of Electronic Engineering, Tsinghua University, Beijing, China. Electronic address:
Out-of-graph node representation learning aims at learning about newly arrived nodes for a dynamic graph. It has wide applications ranging from community detection, recommendation system to malware detection. Although existing methods can be adapted for out-of-graph node representation learning, real-world challenges such as fixed in-graph node embedding and data diversity essentially limit the performance of these methods.
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