AI Article Synopsis

  • The text is a correction for a previously published article identified by its DOI: 10.1039/D3MD00752A.
  • This correction likely addresses errors or inaccuracies found in the original article.
  • Corrections are important in academic publishing to ensure the integrity and reliability of the research presented.

Article Abstract

[This corrects the article DOI: 10.1039/D3MD00752A.].

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110762PMC
http://dx.doi.org/10.1039/d4md90013hDOI Listing

Publication Analysis

Top Keywords

correction aptamer
4
aptamer as1411
4
as1411 interacts
4
interacts kras
4
kras promoter/hnrnp
4
promoter/hnrnp complex
4
complex increased
4
increased potency
4
potency drug-resistant
4
drug-resistant lung
4

Similar Publications

Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation.

View Article and Find Full Text PDF

RNA-Puzzles Round V: blind predictions of 23 RNA structures.

Nat Methods

December 2024

GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, China.

Article Synopsis
  • - RNA-Puzzles is a collaborative project focused on improving the prediction of RNA three-dimensional structures, with predictions made by modeling groups before experimental structures are published.
  • - A significant set of predictions was made by 18 groups for 23 different RNA structures, including various elements like ribozymes and aptamers.
  • - The study highlights key challenges in RNA modeling, such as identifying helix pairs and ensuring proper stacking, and notes that some top-performing groups also excelled in a separate competition (CASP15).
View Article and Find Full Text PDF

Electrochemical aptamer-based (EAB) sensors are the first technology supporting high-frequency, real-time, in vivo molecular measurements that is independent of the chemical reactivity of its targets, rendering it easily generalizable. As is true for all biosensors, however, EAB sensor performance is affected by the measurement environment, potentially reducing accuracy when this environment deviates from the conditions under which the sensor was calibrated. Here, we address this question by measuring the extent to which physiological-scale environmental fluctuations reduce the accuracy of a representative set of EAB sensors and explore the means of correcting these effects.

View Article and Find Full Text PDF

Self-validating photoelectrochemical/photoelectrochromic visual sensing platform for ciprofloxacin precise detection in milk.

Anal Chim Acta

November 2024

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China; Key Laboratory of Modern Agriculture Equipment and Technology, Ministry of Education, School of Agricultural Engineering, Jiangsu University, Zhenjiang, 212013, PR China; Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, OE, School of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, PR China. Electronic address:

Background: In the process of food production, ciprofloxacin (CIP), a highly prescribed fluoroquinolone antibiotic, is often excessively used to reduce the risk of bacterial infection. However, this overuse can cause severe harm to human health, including allergic responses, gastrointestinal complications, and potential renal dysfunction. The development of a robust and precise detection method for CIP is crucial, given the interconnection between food security and human health.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!