AI Article Synopsis
- Stillbirth is a significant public health issue in low and middle-income countries, with varying studies showing conflicting results on the relationship between maternal age and stillbirth risk.
- A systematic review and meta-analysis were conducted to clarify these findings by analyzing data from 14 articles, revealing an odds ratio of 1.42 for stillbirth in women aged 35 and older compared to those aged 20-35, suggesting an increasing risk with advanced maternal age.
- The conclusion emphasizes the need for effective communication about the risks of pregnancy at older ages to all women of reproductive age to address the issue of stillbirth.
Article Abstract
Background And Aims: Stillbirth is a public health as well as a development problem in low and middle-income countries. The studies that found out maternal age as a factor for the risk of stillbirth reported different findings. This systematic review and meta-analysis is believed to fill the inconclusiveness of these findings. Hence, the aim of this systematic review and meta-analysis is to estimate the pooled effect of advanced maternal age on stillbirth in Africa.
Methods: PubMed & HINARY databases and Google Scholar search engine were searched to access the primary studies. The extracted data using Microsoft excel was exported to Stata 15 software for analysis. The presence of heterogeneity was checked using Cochran's statistic and the test. Publication bias was examined by using funnel plot and Egger's test. The pooled effect measure with DerSimonian and Laird method of random-effect model was reported using odds ratio (OR) with respective 95% confidence interval.
Results: Totally, 14 articles are included for the systematic review and meta-analysis. The stillbirth reported by the studies ranges from 15 to 146.7 per 1000 births. The overall OR of advanced maternal age (≥35 years) on stillbirth is 1.42 (1.18, 1.71) when compared with the age group of 20-35 years. The cumulative effect of getting pregnant at advanced age on stillbirth was slightly increasing from year to year.
Conclusion: Advanced maternal age is a risk factor for stillbirth. Health Information Communication on the risk of getting pregnant at the advanced ages on stillbirth should be well addressed to all women of reproductive age group.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11111610 | PMC |
| http://dx.doi.org/10.1002/hsr2.2105 | DOI Listing |
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