AI Article Synopsis
- - The rise of metabolic syndrome, especially in older adults, poses serious health issues, with hyperuricemia (high uric acid) being linked to both gout and age-related macular degeneration (AMD), a major eye disease affecting the elderly.
- - Inflammation plays a key role in the development of AMD, as recent research highlights the impact of uric acid's dual nature—acting as an antioxidant in the bloodstream and a pro-oxidant within cells.
- - There’s a growing indication that high serum uric acid levels may contribute to retinal diseases like AMD, suggesting the need for more research to explore the molecular connections and emphasizing the importance of interdisciplinary collaboration to fully understand these relationships.
Article Abstract
The escalating prevalence of metabolic syndrome poses a significant public health challenge, particularly among aging populations, with metabolic dysfunctions contributing to pro-inflammatory states. In this review, we delved into the less recognized association between hyperuricemia (HUA), a manifestation of metabolic syndrome and a primary risk factor for gout, and age-related macular degeneration (AMD), a sight-threatening ailment predominantly affecting the elderly. In recent years, inflammation, particularly its involvement in complement pathway dysregulation, has gained prominence in AMD pathophysiology. The contradictory role of uric acid (UA) in intercellular and intracellular environments was discussed, highlighting its antioxidant properties in plasma and its pro-oxidant effects intracellularly. Emerging evidence suggests a potential link between elevated serum uric acid levels and choroid neovascularization in AMD, providing insights into the role of HUA in retinal pathologies. Various pathways, including crystal-induced and non-crystal-induced mechanisms, were proposed to indicate the need for further research into the precise molecular interactions. The implication of HUA in AMD underscores its potential involvement in retinal pathologies, which entails interdisciplinary collaboration for a comprehensive understanding of its impact on retina and related clinical manifestations.
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| http://dx.doi.org/10.1096/fj.202400421R | DOI Listing |
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