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| http://dx.doi.org/10.1038/s41598-024-61602-5 | DOI Listing |
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The aluminum standard: using generative Artificial Intelligence tools to synthesize and annotate non-structured patient data.
BMC Med Inform Decis Mak
December 2024
Klinikum Stuttgart, Stuttgart Cancer Center - Tumorzentrum Eva Mayr-Stihl DE, Kriegsbergstraße 60, Stuttgart, D-70174, Germany.
Background: Medical narratives are fundamental to the correct identification of a patient's health condition. This is not only because it describes the patient's situation. It also contains relevant information about the patient's context and health state evolution.
View Article and Find Full Text PDFCAR-T cells are more affected than T lymphocytes by mechanical constraints: A microfluidic-based approach.
Life Sci
December 2024
Department of Mechanical Engineering, University of Zaragoza, Zaragoza, Spain; Instituto de Investigación en Ingeniería de Aragón (I3A), Zaragoza, Spain. Electronic address:
Aims: CAR-T cell therapy has attracted considerable attention in recent years owing to its well-known efficacy against haematopoietic malignancies. Nevertheless, this immunotherapy fails against solid tumours due to hostile conditions found in the tumour microenvironment. In this context, many relevant biochemical factors have been thoroughly studied, but crucial mechanical cues have been underestimated.
View Article and Find Full Text PDFRepeatable process for extracting health data from HL7 CDA documents.
J Biomed Inform
December 2024
Institute of Computer Science, University of Tartu, 51009 Tartu, Estonia; STACC, 51009 Tartu, Estonia.
Objective: This study aims to address the gap in the literature on converting real-world Clinical Document Architecture (CDA) data into the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM), focusing on the initial steps preceding the mapping phase. We highlight the importance of a repeatable Extract-Transform-Load (ETL) pipeline for health data extraction from HL7 CDA documents in Estonia for research purposes.
Methods: We developed a repeatable ETL pipeline to facilitate the extraction, cleaning, and restructuring of health data from CDA documents to OMOP CDM, ensuring a high-quality and structured data format.
Ralstonia pickettii bacteremia: a retrospective review of records.
Indian J Med Microbiol
December 2024
Department of Infectious Diseases, Kasturba Medical College, Manipal; Manipal Academy of Higher Education, Manipal 576104. Electronic address:
Introduction: Ralstonia pickettii is a non-fermenting gram-negative bacillus rarely associated with hospital-acquired infections. The study aimed to characterise the clinical profile and outcomes of R. pickettii bacteremia cases.
View Article and Find Full Text PDFn-butanol extract of Pulsatilla decoction alleviates vulvovaginal candidiasis via the regulation of mitochondria-associated Type I interferon signaling pathways.
J Ethnopharmacol
December 2024
Department of Pathogenic Biology and Immunology, College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine, Hefei, China; Institute of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China. Electronic address:
Ethnopharmacological Relevance: Vulvovaginal candidiasis (VVC) is a relatively common fungal infectious disease in the female reproductive tract. The pathogenesis of VVC not only involves Candida albicans (C. albicans) infection, but also the improper immune response of the vaginal mucosal immune system to the fungus.
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