Fabrication of a novel magnetic nanostructure based on cellulose-gellan gum hydrogel, embedded with MgAl LDH as an efficient catalyst for the synthesis of polyhydroquinoline derivatives.

Nanocatalysts play a vital role in chemical reactions, energy conservation, and pollution control. They significantly contribute to organic synthesis by using natural polymers as nanoparticle substrates in nanocatalysts. Natural hydrogels made from polysaccharide and/or protein sources may be used to accomplish this. Recent research has focused on using layered double-hydroxides (LDHs) in composites having catalytic properties. Magnetic features of the catalyst allow its extraction from the environment using a magnet after the reaction, improving product efficiency. This work developed a catalyst for producing physiologically relevant polyhydroquinoline derivatives using a novel magnetic nanocomposite containing natural cellulose-gellan gum hydrogel and MgAl LDH. The Cell-GG hydrogel/MgAl LDH/FeO nanocomposite showed over 90 % efficiency in one-pot production of polyhydroquinoline derivatives by asymmetric Hantzsch condensation. Dimedone, ammonium acetate, ethyl acetoacetate, and different substituted aldehydes were employed in successive processes to create polyhydroquinoline derivatives. High product efficiency, quick reaction time, room temperature functioning, and easy separation with a magnet suggest a potent catalyst. Interestingly, the catalyst retains 80 % of its original capability after four cycles. Additionally, the Cell-GG hydrogel/MgAl LDH/FeO nanocomposite was analyzed using several methods, including FT-IR, FE-SEM, EDX, XRD, VSM and TGA, to obtain insight into its chemical and physical characteristics.