AI Article Synopsis
- Rutin is a polyphenol with health benefits but has low bioavailability due to solubility and stability issues.
- Encapsulation methods like emulsion systems can enhance the delivery of such compounds, making them a focus of this study.
- The study found that the OVA-FA-κ-carrageenan emulsion better protects rutin from degradation and effectively targets the colon, where rutin is transformed into 4-hydroxybenzoic acid during fermentation.
Article Abstract
Rutin is a polyphenol with beneficial pharmacological properties. However, its bioavailability is often compromised due to low solubility and poor stability. Encapsulation technologies, such as emulsion systems, have been proven to be promising delivery vehicles for enhancing the bioavailability of bioactive compounds. Thus, this study was proposed and designed to investigate the colonic targeting and colonic fermentation characteristics of rutin-loaded ovalbumin-ferulic acid-polysaccharide (OVA-FA-PS) complex emulsions. The results indicate that OVA-FA-PS emulsion effectively inhibits the degradation of rutin active substances and facilitates its transport of rutin to the colon. The analysis revealed that the OVA-FA-κ-carrageenan emulsion loaded with rutin exhibited superior elasticity and colon targeting properties compared to the OVA-FA-hyaluronic acid or OVA-FA-sodium alginate emulsions loaded with rutin in the composite emulsion. Additionally, it was observed that the rutin loaded within the OVA-FA-κ-carrageenan emulsion underwent degradation and was converted to 4-hydroxybenzoic acid during colonic fermentation.
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| http://dx.doi.org/10.1016/j.foodchem.2024.139630 | DOI Listing |
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