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Interventional effects of Pueraria oral liquid on T2DM rats and metabolomics analysis. | LitMetric

Interventional effects of Pueraria oral liquid on T2DM rats and metabolomics analysis.

Biomed Pharmacother

Guizhou Jiandee Technology Co., Ltd., Guiyang 550025, China. Electronic address:

Published: June 2024

AI Article Synopsis

  • Pueraria lobata, also known as kudzu, is a plant with medicinal properties, particularly beneficial for its hypoglycemic, anti-inflammatory, and antioxidant effects, but its specific mechanisms for lowering blood sugar in type 2 diabetes remain unclear.
  • A study was conducted using a Pueraria lobata oral liquid (POL) on rats with type 2 diabetes to evaluate its effects on various health indicators such as blood glucose and liver health, while exploring its action mechanism through metabolomics.
  • Results showed that POL significantly improved weight loss, lowered blood glucose and insulin levels, and provided liver protection, suggesting potential new applications for Pueraria lobata in managing type 2 diabetes.

Article Abstract

Pueraria lobata, commonly known as kudzu, is a medicinal and food plant widely used in the food, health food, and pharmaceutical industries. It has clinical pharmacological effects, including hypoglycemic, antiinflammatory, and antioxidant effects. However, its mechanism of hypoglycemic effect on type 2 diabetes mellitus (T2DM) has not yet been elucidated. In this study, we prepared a Pueraria lobata oral liquid (POL) and conducted a comparative study in a T2DM rat model to evaluate the hypoglycemic effect of different doses of Pueraria lobata oral liquid. Our objective was to investigate the hypoglycemic effect of Puerarin on T2DM rats and understand its mechanism from the perspective of metabolomics. In this study, we assessed the hypoglycemic effect of POL through measurements of FBG, fasting glucose tolerance test, plasma lipids, and liver injury levels. Furthermore, we examined the mechanism of action of POL using hepatic metabolomics. The study's findings demonstrated that POL intervention led to improvements in weight loss, blood glucose, insulin, and lipid levels in T2DM rats, while also providing a protective effect on the liver. Finally, POL significantly affected the types and amounts of hepatic metabolites enriched in metabolic pathways, providing an important basis for revealing the molecular mechanism of Pueraria lobata intervention in T2DM rats. These findings indicate that POL may regulate insulin levels, reduce liver damage, and improve metabolic uptake in the liver. This provides direction for new applications and research on Pueraria lobata to prevent or improve T2DM.

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Source
http://dx.doi.org/10.1016/j.biopha.2024.116780DOI Listing

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