AI Article Synopsis
- Researchers developed a new nanoplatform for cancer treatment using phospholipid-coated upconversion nanoparticles (UCNPs) combined with a photosensitizer called hypocrellin B (HB).
- The method involved creating liposomes that improved the efficiency of energy transfer for better therapeutic outcomes and that had a multi-functional response to the tumor microenvironment.
- This innovative platform demonstrated high effectiveness in treating cancer through a combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT), enhanced by near-infrared (NIR) radiation.
Article Abstract
An antitumour chemo-photodynamic therapy nanoplatform was constructed based on phospholipid-coated NaYF: Yb/Er upconversion nanoparticles (UCNPs). In this work, the amphiphilic block copolymer DSPE-PEG was combined with the surface ligand oleic acid of the UCNPs through hydrophobic interaction to form liposomes with a dense hydrophobic layer in which the photosensitizer hypocrellin B (HB) was assembled. The coated HB formed J-aggregates, which caused a large redshift in the absorption spectrum and improved the quantum efficiency of energy transfer. Furthermore, MnO nanosheets grew in-situ on the liposomes through OMn coordination. Therefore, a multifunctional tumour microenvironment (TME)-responsive theranostic nanoplatform integrating photodynamic therapy (PDT) and chemodynamic therapy (CDT) was successfully developed. The results showed that this NIR-mediated chemo-photodynamic therapy nanoplatform was highly efficient for oncotherapy.
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| http://dx.doi.org/10.1016/j.bioadv.2024.213891 | DOI Listing |
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