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Molecular Therapeutics in Development to Treat Hyperlipoproteinemia.
Mol Diagn Ther
January 2025
Department of Medicine and Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 4288A-1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Clinical endpoints caused by hyperlipoproteinemia include atherosclerotic cardiovascular disease and acute pancreatitis. Emerging lipid-lowering therapies targeting proprotein convertase subtilisin/kexin 9 (PCSK9), lipoprotein(a), apolipoprotein C-III, and angiopoietin-like protein 3 represent promising advances in the management of patients with hyperlipoproteinemia. These therapies offer novel approaches for lowering pathogenic lipid and lipoprotein species, particularly in patients with serious perturbations who are not adequately controlled with conventional treatments or who are unable to tolerate them.
View Article and Find Full Text PDFA proposed algorithm for management of patients with left bundle branch block post-TAVR: 1-year follow-up.
Heart Rhythm O2
December 2024
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Background: Transcatheter aortic valve replacement (TAVR) has revolutionized the management of aortic stenosis and has become the standard of care across a broad spectrum of patients with aortic stenosis. However, it is still associated with high incidence of conduction abnormalities, particularly new left bundle branch block (LBBB). Management of these patients remains a challenge.
View Article and Find Full Text PDFOptimizing Outcomes in Transcatheter Aortic Valve Replacement Addressing Cerebrovascular Complications and Enhancing Patient Safety.
Cardiol Rev
December 2024
From the Departments of Cardiology and Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY.
Article Synopsis
- Transcatheter aortic valve replacement (TAVR) is a key treatment for severe aortic stenosis, widely considered superior to traditional surgical methods.
- Despite its benefits, TAVR carries risks, particularly cerebrovascular complications, which can arise from debris embolization and other procedural factors.
- The review highlights the importance of understanding these complications, discussing their incidence, prevention strategies, and how to improve patient outcomes through better techniques.
Evaluation of Aortic Diseases Using Four-Dimensional Flow Magnetic Resonance Imaging.
Vasc Specialist Int
December 2024
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
The complex hemodynamic environment within the aortic lumen plays a crucial role in the progression of aortic diseases such as aneurysms and dissections. Traditional imaging modalities often fail to provide comprehensive flow dynamics that are essential for precise risk assessment and timely intervention. The advent of time-resolved, three-dimensional (3D) phase-contrast magnetic resonance imaging (4D flow MRI) has revolutionized the evaluation of aortic diseases by allowing a detailed visualizations of flow patterns and quantification of hemodynamic parameters.
View Article and Find Full Text PDFEmpowering EVAR: Revolutionizing Patient Understanding and Qualification with 3D Printing.
J Cardiovasc Dev Dis
November 2024
Department of Vascular Surgery, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Article Synopsis
- The study highlights the importance of better patient education for those undergoing endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA).
- Researchers created 3D-printed models of patients' aneurysms to help explain their condition and treatment, leading to a significant increase in patients' knowledge after educational sessions.
- Patients found the 3D models very helpful in understanding their condition and treatment, indicating a positive impact on patient engagement in their healthcare decisions.
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