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| http://dx.doi.org/10.1016/j.ymthe.2024.05.025 | DOI Listing |
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The role of the conditioning regimen for autologous and ex vivo genetically modified hematopoietic stem cell-based therapies: recommendations from the ISCT stem cell engineering committee.
Cytotherapy
January 2025
Center for Cancer and Immunology Research, CETI, Children's National Hospital, Washington, District of Columbia, USA.
Article Synopsis
- Autologous gene modified cell therapies show promise for treating monogenic disorders, representing a significant advance in hematopoietic stem cell transplantation and cellular therapies.
- The manuscript reviews clinical data on various conditioning regimens used for these therapies across different disorders like hemoglobinopathies, metabolic issues, and bone marrow failures.
- Recommendations are proposed to standardize treatments for these disorders, and the authors explore potential future options for non-genotoxic conditioning regimens.
A modular strategy for the testing and assessment of non-genotoxic carcinogens.
Arch Toxicol
August 2024
UK Health Security Agency, Radiation, Chemical and Environmental Hazards, Harwell Science and Innovation Campus, Chilton, Oxfordshire, OX11 0RQ, UK.
A modular strategy is described for the testing and assessment (MoSt) of non-genotoxic carcinogenicity (NGTxC) that is suitable for regulatory applications. It utilizes and builds upon work conducted by the OECD expert group on NGTxC. The approach integrates relevant test methods from the molecular- to cellular- and further to tissue level, many of which have been recently reviewed.
View Article and Find Full Text PDFA new step toward non-genotoxic conditioning prior to hematopoietic stem cell transplantation.
Mol Ther
June 2024
Université Paris Cité, Paris, France; Department of Paediatric Immunology and Haematology, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Institut de Recherche Saint-Louis, INSERM U976, Paris, France.
Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps.
Front Toxicol
March 2024
Université Paris Cité, Inserm UMR-S 1124 T3S, Paris, France.
The Adverse Outcome Pathway (AOP) concept facilitates rapid hazard assessment for human health risks. AOPs are constantly evolving, their number is growing, and they are referenced in the AOP-Wiki database, which is supported by the OECD. Here, we present a study that aims at identifying well-defined biological areas, as well as gaps within the AOP-Wiki for future research needs.
View Article and Find Full Text PDFDNA methylation changes from primary cultures through senescence-bypass in Syrian hamster fetal cells initially exposed to benzo[a]pyrene.
Toxicology
March 2023
Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, K1A 0K9, Canada. Electronic address:
Current chemical testing strategies are limited in their ability to detect non-genotoxic carcinogens (NGTxC). Epigenetic anomalies develop during carcinogenesis regardless of whether the molecular initiating event is associated with genotoxic (GTxC) or NGTxC events; therefore, epigenetic markers may be harnessed to develop new approach methodologies that improve the detection of both types of carcinogens. This study used Syrian hamster fetal cells to establish the chronology of carcinogen-induced DNA methylation changes from primary cells until senescence-bypass as an essential carcinogenic step.
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