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Systemic ALK-negative anaplastic large cell lymphoma: Insights into morphologic, immunophenotypic, genetic and molecular characteristics.
Hum Pathol
October 2024
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA. Electronic address:
Anaplastic large cell lymphoma (ALCL) is a mature T-cell neoplasm characterized by large pleomorphic cells, often with horseshoe- or kidney-shaped nuclei and abundant cytoplasm (hallmark cells), and uniformly strong CD30 expression. Based on ALK expression or ALK rearrangement, ALCL is further classified into ALK-positive (ALK+) and ALK-negative types. This review focuses on the clinicopathologic, immunophenotypic, cytogenetic and molecular features of systemic ALK-negative ALCL.
View Article and Find Full Text PDFSenescence-Associated T cells in Immunosenescence and Diseases.
Int Immunol
September 2024
Laboratory of Tumor Tissue Response, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Age-related changes in the immune system, referred to as immunosenescence, appear to evolve with rather paradoxical manifestations, a diminished adaptive immune capacity, and an increased propensity for chronic inflammation often with autoimmunity, which may underlie the development of diverse disorders with age. Immunosenescent phenotypes are associated with the emergence of unique lymphocyte subpopulations of both T and B lineages. We report that a CD153+ PD-1+ CD4+ T-cell subpopulation with severely attenuated T-cell receptor (TCR)-responsiveness, termed senescence-associated T (SAT) cells, co-evolve with potentially autoreactive CD30+ B cells, such as spontaneous germinal center B cells and age-associated B cells, in aging mice.
View Article and Find Full Text PDFEpigenetic agents plus anti-PD-1 reprogram the tumor microenvironment and restore antitumor efficacy in Hodgkin lymphoma.
Blood
October 2024
Department of Biotherapeutics, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.
Article Synopsis
- A study evaluated a triplet therapy of chidamide, decitabine, and camrelizumab (CDP) in patients with relapsed/refractory classic Hodgkin lymphoma (cHL) who previously underwent DNA methyltransferase inhibitor decitabine plus anti-PD-1 therapy.
- CDP treatment was well-received, with a 94% objective response rate and 50% of patients achieving complete response, even in those who initially resisted DP therapy.
- Research using single-cell RNA sequencing revealed interactions between malignant cells and immunosuppressive T cells, indicating that CDP treatment enhances anti-tumor responses while reducing immunosuppressive effects, offering a promising approach to overcoming immunotherapy resistance.
An Unusual Clinical Presentation of Traumatic Ulcerative Granuloma With Stromal Eosinophilia.
J Oral Maxillofac Surg
October 2024
Clinical Assistant Professor, Stony Brook School of Dental Medicine, Department of Oral and Maxillofacial Surgery, Stony Brook, NY.
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a reactive and chronic ulcerative lesion that is most frequently found on the tongue. It appears as a large yellowish ulcer with elevated margins and central induration. TUGSEs exhibit a characteristic pattern of regression often spontaneously, following incisional biopsy, or after removal of the potential traumatic trigger.
View Article and Find Full Text PDFAbundant CD30+ lymphocyte infiltrate in idiopathic perniosis.
Ann Dermatol Venereol
June 2024
Department of Dermatology, Hôpital Saint-André, CHU de Bordeaux, Bordeaux, France.
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