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Symmetrical structure design of PLGA Biodegradable sinus stents and structure optimization based on surrogate models. | LitMetric

Symmetrical structure design of PLGA Biodegradable sinus stents and structure optimization based on surrogate models.

Comput Methods Biomech Biomed Engin

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

Published: May 2024

AI Article Synopsis

Article Abstract

This study aims to enhance the degradation uniformity of PLGA sinus stents to minimize fracture risk caused by stress corrosion. Symmetric stent structures were introduced and compared to sinusoidal structure in terms of stress and degradation uniformity during implantation and degradation processes. Three surrogate models were employed to optimize the honeycomb-like structure. Results showed honeycomb-like structures exhibited the superior stress distribution and highest degradation uniformity. The kriging model achieved the smallest error and degradation uniformity of 83.24%. In conclusion, enhancing the symmetry of stent structures improves degradation uniformity, and the kriging model has potential for the optimization of stent structures.

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Source
http://dx.doi.org/10.1080/10255842.2024.2355491DOI Listing

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