Objective: With same-day online alcohol sales increasing, there is a need to study their regulation. Test purchasing of alcohol home delivery was conducted to measure compliance with regulations for identification checks and unattended deliveries in two Australian jurisdictions (Perth, Western Australia, and Geelong, Victoria), which have differing regulations.
Method: Alcohol orders for same-day or rapid (<2 hours) delivery on Friday and Saturday nights were made by research assistants ages 18-24 years in Perth ( = 34) and Geelong ( = 29). An observation checklist was used to record the delivery interaction, with a specific focus on checking photo identification at the time of delivery and whether deliveries were left unattended.
Results: The average time from order to delivery for rapid deliveries was less than 1 hour in both sites (Perth = 50 minutes; Geelong = 36 minutes). More than 20% of deliveries were made without an identification check in both sites (Perth = 24%; Geelong = 21%).
Conclusions: This pilot study showed that alcohol can be delivered to the home within 1 hour, and not all deliveries include an identification check at the point of delivery. These findings indicate a need for policies that empower regulators and police to undertake "mystery shopper" monitoring to reduce potential harms and improve compliance with alcohol delivery policy.
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http://dx.doi.org/10.15288/jsad.23-00223 | DOI Listing |
PLoS One
January 2025
Faculty of Business, City University of Macau, Macao, China.
Based on the previous studies on the impact of traditional culture on tourists' purchasing intentions, this study aims to further explore the mechanism and boundary conditions regarding the traditional cultural load in tourist souvenir packaging. Through seven simulated experiments (N = 3203), the impact of different degrees of traditional cultural load on tourists' purchasing intentions has been examined, with value perception, cultural identity, and purchase purpose, advancing the research in the field of traditional culture and tourism marketing. The findings provide insights for managers in the industry of tourism and souvenir marketing for their package design.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Cognition Therapeutics, Inc, Pittsburgh, PA, USA.
Background: The sigma-2 receptor (S2R) modulator CT1812 is a first-in-class investigational therapeutic, currently in Phase 2 clinical trials for Alzheimer's disease (AD). Preclinical and clinical studies have shown that CT1812 displaces Aβ oligomers from synapses and clears them from the brain into the cerebrospinal fluid, restoring cognitive performance in a transgenic mouse model of AD. To investigate the mechanism of action of CT1812 and enable biomarker discovery, a phosphoproteomic analysis of CSF samples from SHINE-A was performed.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Cognition Therapeutics, Inc, Pittsburgh, PA, USA.
Background: A Phase 2 randomized, double-blind, placebo-controlled 6-month trial, SHINE (NCT03507790), was designed to include up to 144 participants with mild to moderate Alzheimer's disease (AD) to study the effects of the sigma-2 receptor (S2R) modulator CT1812 on cognition, safety, and biomarkers. CSF canonical and exploratory biomarkers were assessed to determine treatment effects with CT1812.
Method: Participants (n = 153) received a daily oral dose of either CT1812 (100 mg or 300 mg) or placebo during the treatment period of 6-months.
Alzheimers Dement
December 2024
Cognition Therapeutics, Inc, Pittsburgh, PA, USA.
Background: SHINE (NCT03507790, COG0201) is a Phase 2 randomized, double-blind, placebo-controlled 6-month trial, conducted to study the effect of the sigma-2 receptor (S2R) modulator CT1812 in patients with Alzheimer's disease (AD). An unbiased assessment of CSF proteomes from the patients that completed the SHINE trial was performed to identify pharmacodynamic (PD) biomarkers of target/pathway engagement and disease modification for CT1812.
Method: Tandem-mass tag mass spectrometry (TMT-MS) CSF proteomics was performed on baseline and end of study samples from an analysis of SHINE Part A and B to test the effects of two doses (100 mg, 300 mg; given orally, once daily) of CT1812 compared to placebo in mild to moderate AD patients.
Public Health Nutr
January 2025
Department of Epidemiology, Human Genetics, and Environmental Science, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030. USA.
Objective: We qualitatively examine the grocery shopping behaviors and fruit and vegetable consumption of low-income families participating in the Brighter Bites program in Houston, Texas.
Design: We used a single-group observational study design. We used (1) purposive sampling of schools and (2) convenience sampling of parents/caregivers to recruit participants.
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