The cornea and sclera are distinct adjacent tissues, yet their stromal cells originate from common neural crest cells (NCCs). Sclerocornea is a disease characterized by an indistinguishable boundary between the cornea and sclera. Previously, we identified a mutation in a sclerocornea pedigree. Here, we investigated the impacts of on NCC activities during eye development. deficiency caused upregulation of . Both knockdown and upregulation disrupted the migration of NCCs. Transcriptome analysis indicated that had 190.9-fold higher expression in scleral stroma than in corneal stroma. was also significantly upregulated by both knockdown and overexpression, and knock down of rescued the differentiation and migration of NCCs with deficiency. Consistently, overexpressing in led to ocular developmental abnormalities. In summary, WNT9B is a determinant factor during NCC differentiation into corneal keratocytes or scleral stromal cells and is affected by RAD21 expression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107359 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.109875 | DOI Listing |
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