AI Article Synopsis
- - Sebaceous carcinoma is a rare type of cancer, especially affecting the trunk and extremities, and there is limited knowledge about its demographics and treatment options.
- - An analysis of over 3,200 cases from the National Cancer Database between 2004 and 2016 revealed that 26% of these tumors were located on the trunk and extremities, which tend to be larger and more well differentiated compared to those on the head and neck.
- - The main treatment for sebaceous carcinoma is surgery, with radiotherapy being the second most common approach and chemotherapy rarely used.
Article Abstract
Background: Sebaceous carcinoma is a rare cancer, and little is known about its current epidemiology and treatment. This is particularly true for sebaceous carcinomas of the trunk and extremities.
Objective: We present a database analysis of sebaceous carcinoma cases to further delineate demographics, location, tumor characteristics, and treatment modalities among patients diagnosed with these tumors.
Methods: The National Cancer Database was queried for cases of sebaceous carcinoma between 2004 and 2016. 3211 cases were analyzed for descriptive and comparative statistics.
Results: Twenty-six percent of sebaceous carcinomas were found on the trunk and extremities. Tumors on the trunk and extremities were more likely to be larger than tumors on the head and neck, with 8% being greater than 50 mm ( < .001). Tumors on the trunk and extremities were more likely to be well differentiated ( < .001) and have fewer lymph node metastases ( < .001). Surgery was the primary treatment modality for tumors, followed by radiotherapy and rarely chemotherapy.
Conclusions: Sebaceous cancer is a poorly understood entity. We demonstrated that trunk and extremity tumors tend to be larger and more differentiated than those of the head and neck. Treatment practices are varied at this time, but surgery is the primary modality.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107211 | PMC |
| http://dx.doi.org/10.1016/j.jdin.2024.03.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Carcinoma in a male accessory breast; Case report with literature review.
Int J Surg Case Rep
January 2025
Breast and Endocrine Surgery Consultant, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
Introduction And Importance: Accessory breast is a rare condition where regression of the mammary ridge fails. This ectopic breast can function as the same pectoral breast and respond to hormonal effects. Furthermore, in rare cases, it can develop into malignancy.
View Article and Find Full Text PDFA novel microsatellite instability test of sebaceous tumours to facilitate low cost universal screening for Lynch syndrome.
Clin Exp Dermatol
January 2025
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Background: One in five sebaceous tumour (ST) patients may have Lynch syndrome (LS), a hereditary cancer predisposition. LS patients benefit from cancer surveillance and prevention programmes and immunotherapy. Whilst universal tumour mismatch repair (MMR) deficiency testing is recommended in colorectal and endometrial cancers to screen for LS, there is no consensus screening strategy for ST, leading to low testing rates and inequity of care.
View Article and Find Full Text PDFCase report: Basal cell carcinoma arising within the nevus sebaceous: report of 4 cases and literature review.
Front Oncol
January 2025
Department of Dermatovenereology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Nevus sebaceous (NS) is a congenital hamartoma characterized by the presence of skin structures, including the epidermis, sebaceous glands, and hair follicles. NS predominantly occurs on the scalp and has the potential to give rise to secondary tumors, with a small proportion being malignant; the most frequently observed malignant tumor associated with NS is basal cell carcinoma. In this report, we retrospectively present four cases of sebaceous nevus on the scalp complicated by basal cell carcinoma.
View Article and Find Full Text PDFSebaceous carcinoma: clinical and demographic profile of patients in a tertiary referral hospital in Brazil.
An Bras Dermatol
January 2025
Department of Dermatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:
Clinical characteristics and prognostic factors of extraocular sebaceous carcinoma: a retrospective study.
Arch Dermatol Res
January 2025
Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, 40126, Italy.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!