AI Article Synopsis
- Brain metastases from ovarian cancer are uncommon, and spinal cord metastases are even rarer, representing only 0.4% of all metastatic spinal cord compressions.
- A case study involves a woman in her 70s who developed brain and spinal cord metastases during treatment for high-grade serous ovarian cancer, without any specific genetic mutations.
- The report emphasizes the unusual nature of this case, discusses potential underlying disease mechanisms and treatment resistance, and highlights the importance of a multidisciplinary approach in managing such complex conditions.
Article Abstract
Brain metastases (BMs) arising from ovarian cancer remain rare. Spinal cord metastases are even rarer, accounting for just 0.4% of total metastatic spinal cord compressions. In this report, we describe a case of a woman in her 70s who developed sequential brain and spinal cord metastases during her treatment for high-grade serous ovarian cancer, without a germline or somatic mutation. Following completion of neoadjuvant chemotherapy, interval debulking surgery and adjuvant chemotherapy, relapsed disease was ultimately identified as a single BM, curiously mimicking an acoustic neuroma. Subsequently, spinal cord metastases rapidly developed. Throughout, multidisciplinary team meetings guided decisions on patient management. In this report, we highlight the rarity of such a presentation and discuss the possible role of disease pathophysiology, associated systemic anticancer therapy resistance, and treatment possibilities for both cerebral and spinal metastases.
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| http://dx.doi.org/10.1136/bcr-2023-259144 | DOI Listing |
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