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| http://dx.doi.org/10.1007/s00259-024-06769-9 | DOI Listing |
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Development of STING probes and visualization of STING in multiple tumor types.
Eur J Nucl Med Mol Imaging
January 2025
State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, 4221-116 Xiang'An South Rd, Xiamen, 361102, China.
Article Synopsis
- The study focused on developing a non-invasive imaging platform to monitor STING expression in tumors, which is crucial for enhancing tumor immunotherapy.
- Researchers used a specific radioprobe for positron emission tomography (PET) to assess STING levels in different tumor models and optimized the probe's structure to improve its effectiveness in imaging.
- Results indicated a strong correlation between the amount of STING in tumors and the radioprobe uptake in PET imaging, leading to better visualization of tumors while minimizing non-targeted exposure.
STING-targeted PET imaging: unveiling tumor immunogenicity post-chemotherapy in colorectal cancer.
Eur J Nucl Med Mol Imaging
July 2024
Department of Respiratory and Critical Care Medicine, Center for Oncology Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
STING-Targeted PET Imaging for Specific Detection and Therapeutic Monitoring of Myocarditis.
Mol Pharm
June 2024
Department of Emergency Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China.
Imaging strategies for the specific detection and therapeutic monitoring of myocarditis are still lacking. Stimulator of interferon genes (STING) is a signal transduction molecule involved in an innate immune response. Here, we evaluated the feasibility of the recently developed STING-targeted radiotracer [F]FBTA for positron emission tomography (PET) imaging to detect myocardial inflammation and monitor treatment in myocarditis mice.
View Article and Find Full Text PDFSTING-targeted PET tracer for early assessment of tumor immunogenicity in colorectal cancer after chemotherapy.
Eur J Nucl Med Mol Imaging
February 2024
Department of Nuclear Medicine, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, China.
Purpose: To optimize chemotherapy regimens and improve the effectiveness of chemotherapy combined with immunotherapy, a PET tracer specifically targeting the stimulator of interferon genes (STING), denoted as [F]FBTA was used to monitor the early changes in tumor immunogenicity after chemotherapy in colorectal cancer (CRC) mice.
Methods: The toluene sulfonate precursor was labeled with F to produce the STING targeted probe-[F]FBTA. [F]FBTA-PET imaging and biodistribution were performed using CRC mice treated with oxaliplatin (OXA) or cisplatin (CDDP).
Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury.
Acta Pharm Sin B
May 2023
Department of Nuclear Medicine, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China.
Acute lung injury (ALI), as a common clinical emergency, is pulmonary edema and diffuse lung infiltration caused by inflammation. The lack of non-invasive alert strategy, resulting in failure to carry out preventive treatment, means high mortality and poor prognosis. Stimulator of interferon genes (STING) is a key molecular biomarker of innate immunity in response to inflammation, but there is still a lack of STING-targeted strategy.
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